Communications Biology (Dec 2021)

Chemokines modulate glycan binding and the immunoregulatory activity of galectins

  • Lucía Sanjurjo,
  • Iris A. Schulkens,
  • Pauline Touarin,
  • Roy Heusschen,
  • Ed Aanhane,
  • Kitty C. M. Castricum,
  • Tanja D. De Gruijl,
  • Ulf J. Nilsson,
  • Hakon Leffler,
  • Arjan W. Griffioen,
  • Latifa Elantak,
  • Rory R. Koenen,
  • Victor L. J. L. Thijssen

DOI
https://doi.org/10.1038/s42003-021-02922-4
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 11

Abstract

Read online

Sanjurjo et al investigate the role of galectins in immunomodulation, reporting that chemokines can control galectin immunomodulatory function through a mechanism involving galectin-chemokine binding pairs. Specifically, the authors find that CXCL4 binding changes the galectin-1 carbohydrate binding site, altering the glycan-binding affinity and specificity of galectin-1, as well as increasing the apoptotic activity of galectin-1 on CD8+ T cells.