Communications Biology (Dec 2021)
Chemokines modulate glycan binding and the immunoregulatory activity of galectins
Abstract
Sanjurjo et al investigate the role of galectins in immunomodulation, reporting that chemokines can control galectin immunomodulatory function through a mechanism involving galectin-chemokine binding pairs. Specifically, the authors find that CXCL4 binding changes the galectin-1 carbohydrate binding site, altering the glycan-binding affinity and specificity of galectin-1, as well as increasing the apoptotic activity of galectin-1 on CD8+ T cells.