Nature Communications (Feb 2020)

Liver governs adipose remodelling via extracellular vesicles in response to lipid overload

  • Yue Zhao,
  • Meng-Fei Zhao,
  • Shan Jiang,
  • Jing Wu,
  • Jia Liu,
  • Xian-Wen Yuan,
  • Di Shen,
  • Jing-Zi Zhang,
  • Nan Zhou,
  • Jian He,
  • Lei Fang,
  • Xi-Tai Sun,
  • Bin Xue,
  • Chao-Jun Li

DOI
https://doi.org/10.1038/s41467-020-14450-6
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 17

Abstract

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Extracellular vesicles (EVs) containing miRNAs or proteins can coordinate metabolic responses between tissues. Here the authors demonstrate that during lipid overload, the liver secretes miRNA-containing EVs through a Ggpps-Rab27 dependent mechanism, which controls adipose tissue lipid storage capacity.