Changes in the Structural and Functional State of Bone Tissue, the Level of Osteoprotegerin in Women with Ischemic Heart Disease in Postmenopause

Abstract

Epidemiological evidence of the correlation in development of osteoporosis and cardiovascular diseases in menopause are actively discussed. The objective of the study was to determine the changes in the structural and functional state of the skeletal system, the level of osteoprotegerin in women with ischemic heart disease in postmenopause. The study involved 148 postmenopausal women, they were divided into groups depending on the presence of ischemic heart disease and osteoporosis (mean age 63.5 ± 5.9 years, duration of postmenopause on average — 6.10 ± 0.65 years). Everyone underwent densitometric examination, identification of markers of resorption and bone formation, osteoprotegerin. The results showed that in postmenopausal women with ischemic heart disease in the presence of osteoporosis more significant decrease in T-scores, levels of osteocalcin and osteoprotegerin was defined.

Keywords

• menopause
• osteoporosis
• ischemic heart disease
• osteoprotegerin