SARS-CoV-2 vaccination induces mucosal antibody responses in previously infected individuals

Kaori Sano; Disha Bhavsar; Gagandeep Singh; Daniel Floda; Komal Srivastava; Charles Gleason; PARIS Study Group; Juan Manuel Carreño; Viviana Simon; Florian Krammer

doi:10.1038/s41467-022-32389-8

Nature Communications (Sep 2022)

SARS-CoV-2 vaccination induces mucosal antibody responses in previously infected individuals

Kaori Sano,
Disha Bhavsar,
Gagandeep Singh,
Daniel Floda,
Komal Srivastava,
Charles Gleason,
PARIS Study Group,
Juan Manuel Carreño,
Viviana Simon,
Florian Krammer

Affiliations

Kaori Sano: Department of Microbiology, Icahn School of Medicine at Mount Sinai
Disha Bhavsar: Department of Microbiology, Icahn School of Medicine at Mount Sinai
Gagandeep Singh: Department of Microbiology, Icahn School of Medicine at Mount Sinai
Daniel Floda: Department of Microbiology, Icahn School of Medicine at Mount Sinai
Komal Srivastava: Department of Microbiology, Icahn School of Medicine at Mount Sinai
Charles Gleason: Department of Microbiology, Icahn School of Medicine at Mount Sinai
PARIS Study Group
Juan Manuel Carreño: Department of Microbiology, Icahn School of Medicine at Mount Sinai
Viviana Simon: Department of Microbiology, Icahn School of Medicine at Mount Sinai
Florian Krammer: Department of Microbiology, Icahn School of Medicine at Mount Sinai

DOI: https://doi.org/10.1038/s41467-022-32389-8
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 8

Abstract

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Prior exposure to infectious agents can impact the vaccination induced immune response. Here the authors show prior SARS-CoV-2 infection results in more efficient induction of mucosal SARS-CoV-2 secretory IgA antibody following mRNA vaccination.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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