Nature Communications (Mar 2016)

Lysosome triggered near-infrared fluorescence imaging of cellular trafficking processes in real time

  • Marco Grossi,
  • Marina Morgunova,
  • Shane Cheung,
  • Dimitri Scholz,
  • Emer Conroy,
  • Marta Terrile,
  • Angela Panarella,
  • Jeremy C. Simpson,
  • William M. Gallagher,
  • Donal F. O’Shea

DOI
https://doi.org/10.1038/ncomms10855
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 13

Abstract

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Real time cellular fluorescence imaging requires a probe that displays high degrees of localisation, low toxicity and good photostability. Here, the authors report a near infrared fluorophore that displays pH-sensitive fluorescence based on phenol/phenolate interconversion, showing real time imaging of cellular processes.