Frontiers in Oncology (Apr 2024)
Rapid identification of pediatric brain tumors with differential mobility spectrometry
- Ilkka Haapala,
- Ilkka Haapala,
- Ilkka Haapala,
- Anton Rauhameri,
- Anton Rauhameri,
- Meri Mäkelä,
- Meri Mäkelä,
- Markus Karjalainen,
- Markus Karjalainen,
- Anton Kontunen,
- Anton Kontunen,
- Anton Kontunen,
- Markus Mieskolainen,
- Markus Mieskolainen,
- Hannu Haapasalo,
- Hannu Haapasalo,
- Antti Roine,
- Antti Roine,
- Niku Oksala,
- Niku Oksala,
- Niku Oksala,
- Antti Vehkaoja,
- Antti Vehkaoja,
- Joonas Haapasalo,
- Joonas Haapasalo,
- Joonas Haapasalo,
- Kristiina Nordfors,
- Kristiina Nordfors,
- Kristiina Nordfors
Affiliations
- Ilkka Haapala
- Department of Neurosurgery, Tampere University Hospital, Wellbeing Services County of Pirkanmaa, Tampere, Finland
- Ilkka Haapala
- Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
- Ilkka Haapala
- TAYS Cancer Center, Tampere University Hospital, Wellbeing Services County of Pirkanmaa, Tampere, Finland
- Anton Rauhameri
- Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
- Anton Rauhameri
- TAYS Cancer Center, Tampere University Hospital, Wellbeing Services County of Pirkanmaa, Tampere, Finland
- Meri Mäkelä
- TAYS Cancer Center, Tampere University Hospital, Wellbeing Services County of Pirkanmaa, Tampere, Finland
- Meri Mäkelä
- Olfactomics Ltd., Tampere, Finland
- Markus Karjalainen
- TAYS Cancer Center, Tampere University Hospital, Wellbeing Services County of Pirkanmaa, Tampere, Finland
- Markus Karjalainen
- Olfactomics Ltd., Tampere, Finland
- Anton Kontunen
- Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
- Anton Kontunen
- TAYS Cancer Center, Tampere University Hospital, Wellbeing Services County of Pirkanmaa, Tampere, Finland
- Anton Kontunen
- Olfactomics Ltd., Tampere, Finland
- Markus Mieskolainen
- Department of Neurosurgery, Tampere University Hospital, Wellbeing Services County of Pirkanmaa, Tampere, Finland
- Markus Mieskolainen
- TAYS Cancer Center, Tampere University Hospital, Wellbeing Services County of Pirkanmaa, Tampere, Finland
- Hannu Haapasalo
- TAYS Cancer Center, Tampere University Hospital, Wellbeing Services County of Pirkanmaa, Tampere, Finland
- Hannu Haapasalo
- Fimlab Laboratories Ltd., Tampere, Finland
- Antti Roine
- TAYS Cancer Center, Tampere University Hospital, Wellbeing Services County of Pirkanmaa, Tampere, Finland
- Antti Roine
- Olfactomics Ltd., Tampere, Finland
- Niku Oksala
- Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
- Niku Oksala
- TAYS Cancer Center, Tampere University Hospital, Wellbeing Services County of Pirkanmaa, Tampere, Finland
- Niku Oksala
- Olfactomics Ltd., Tampere, Finland
- Antti Vehkaoja
- Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
- Antti Vehkaoja
- TAYS Cancer Center, Tampere University Hospital, Wellbeing Services County of Pirkanmaa, Tampere, Finland
- Joonas Haapasalo
- Department of Neurosurgery, Tampere University Hospital, Wellbeing Services County of Pirkanmaa, Tampere, Finland
- Joonas Haapasalo
- Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
- Joonas Haapasalo
- TAYS Cancer Center, Tampere University Hospital, Wellbeing Services County of Pirkanmaa, Tampere, Finland
- Kristiina Nordfors
- Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
- Kristiina Nordfors
- TAYS Cancer Center, Tampere University Hospital, Wellbeing Services County of Pirkanmaa, Tampere, Finland
- Kristiina Nordfors
- Department of Pediatrics, Tampere University Hospital, Wellbeing Services County of Pirkanmaa, Tampere, Finland
- DOI
- https://doi.org/10.3389/fonc.2024.1352509
- Journal volume & issue
-
Vol. 14
Abstract
IntroductionBrain tumors are a major source of disease burden in pediatric population, with the most common tumor types being pilocytic astrocytoma, ependymoma and medulloblastoma. In every tumor entity, surgery is the cornerstone of treatment, but the importance of gross-total resection and the corresponding patient prognosis is highly variant. However, real-time identification of pediatric CNS malignancies based on the histology of the frozen sections alone is especially troublesome. We propose a novel method based on differential mobility spectrometry (DMS) analysis for rapid identification of pediatric brain tumors.MethodsWe prospectively obtained tumor samples from 15 pediatric patients (5 pilocytic astrocytomas, 5 ependymomas and 5 medulloblastomas). The samples were cut into 36 smaller specimens that were analyzed with the DMS.ResultsWith linear discriminant analysis algorithm, a classification accuracy (CA) of 70% was reached. Additionally, a 75% CA was achieved in a pooled analysis of medulloblastoma vs. gliomas.DiscussionOur results show that the DMS is able to differentiate most common pediatric brain tumor samples, thus making it a promising additional instrument for real-time brain tumor diagnostics.
Keywords
- differential mobility spectrometry
- neuro-oncology
- pediatric neuro-oncology
- pediatric brain tumor
- rapid diagnostics
