Clinical laboratory characteristic of hospitalized patients with HBsAg negative chronic hepatitis B

Abstract

One of the phases of the natural course of chronic hepatitis В is «HBsAg negative» phase, the clinical and prognostic significance of which is not defined yet. The frequency of HBsAg negative phase of chronic hepatitis В among the hospitalized patients of Clinical Infectious Diseases Hospital named by S.P. Botkin (Saint-Petersburg), for the period of 2010–2012 was assessed in this study. We analyzed the age structure of the patients, their clinical-laboratory inde[es and set the frequency of cirrhotic stage of disease. The «HBsAg negative» phase is revealed among quarter of patients with chronic hepatitis В the middle aged group (45–59 years old). The 84 (67,2%) hospitalized patients with HBsAg negative chronic hepatitis В diagnosed were given a diagnosis of cirrhotic stage disease. Thus, the spontaneous clearance of HBsAg from blood serum is not always the evidence of the prognostically favorable course of chronic hepatitis B.

Keywords

• chronic hepatitis b
• “hbsag negative” phase
• cirrhosis