Nature Communications (Apr 2020)
NPM1 upregulates the transcription of PD-L1 and suppresses T cell activity in triple-negative breast cancer
- Ge Qin,
- Xin Wang,
- Shubiao Ye,
- Yizhuo Li,
- Miao Chen,
- Shusen Wang,
- Tao Qin,
- Changlin Zhang,
- Yixin Li,
- Qian Long,
- Huabin Hu,
- Dingbo Shi,
- Jiaping Li,
- Kai Zhang,
- Qinglian Zhai,
- Yanlai Tang,
- Tiebang Kang,
- Ping Lan,
- Fangyun Xie,
- Jianjun Lu,
- Wuguo Deng
Affiliations
- Ge Qin
- Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine
- Xin Wang
- Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine
- Shubiao Ye
- The Sixth Affiliated Hospital, Sun Yat-sen University
- Yizhuo Li
- Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine
- Miao Chen
- Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine
- Shusen Wang
- Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine
- Tao Qin
- Sun Yat-sen Memorial Hospital, Sun Yat-sen University
- Changlin Zhang
- Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine
- Yixin Li
- Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine
- Qian Long
- Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine
- Huabin Hu
- The Sixth Affiliated Hospital, Sun Yat-sen University
- Dingbo Shi
- Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine
- Jiaping Li
- Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine
- Kai Zhang
- Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine
- Qinglian Zhai
- Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine
- Yanlai Tang
- The First Affiliated Hospital, Sun Yat-sen University
- Tiebang Kang
- Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine
- Ping Lan
- The Sixth Affiliated Hospital, Sun Yat-sen University
- Fangyun Xie
- Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine
- Jianjun Lu
- The First Affiliated Hospital, Sun Yat-sen University
- Wuguo Deng
- Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine
- DOI
- https://doi.org/10.1038/s41467-020-15364-z
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 16
Abstract
PD-L1 is highly expressed in triple-negative breast cancers (TNBC). Here, the authors show that nucleophosmin 1 (NPM1) transcriptionally activates PD-L1 expression and inhibits T cell activity in TNBC.
