Frontiers in Neurology (May 2018)

Progressive Demyelination in the Presence of Serum Myelin Oligodendrocyte Glycoprotein-IgG: A Case Report

  • Sara Gil-Perotin,
  • Sara Gil-Perotin,
  • Jéssica Castillo-Villalba,
  • Joan Carreres-Polo,
  • Arantxa Navarré-Gimeno,
  • Javier Mallada-Frechín,
  • Francisco Pérez-Miralles,
  • Francisco Pérez-Miralles,
  • Francisco Gascón,
  • Carmen Alcalá-Vicente,
  • Carmen Alcalá-Vicente,
  • Laura Cubas-Nuñez,
  • Bonaventura Casanova-Estruch,
  • Bonaventura Casanova-Estruch

DOI
https://doi.org/10.3389/fneur.2018.00340
Journal volume & issue
Vol. 9

Abstract

Read online

The clinical diagnosis of patients with autoantibodies directed to conformational myelin oligodendrocyte glycoprotein MOG-IgG, can be challenging because of atypical clinical presentation. MOG-IgG seropositivity has been reported in several demyelinating diseases, including relapsing opticospinal syndromes [in the neuromyelitis optica spectrum disorders (NMOSD) and less frequently, in multiple sclerosis (MS)], but it has rarely been associated with the progressive course of disease. To contribute to the characterization of MOG-related demyelination, we describe the case of a patient with progressive demyelinating opticospinal disease, IgG-oligoclonal bands (OCB), and serum MOG-IgG.

Keywords