Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse models

Abstract

The human TNFAIP3 gene, which encodes for A20, is associated with autoimmune diseases. Here, the authors use BAC transgenics combined with CRISPR- and recombineering-mediated genome editing to dissect in vivo and in primary immune cells, the role of enhancers regulating TNFAIP3.