Nature Communications (Feb 2020)
Neurology-related protein biomarkers are associated with cognitive ability and brain volume in older age
- Sarah E. Harris,
- Simon R. Cox,
- Steven Bell,
- Riccardo E. Marioni,
- Bram P. Prins,
- Alison Pattie,
- Janie Corley,
- Susana Muñoz Maniega,
- Maria Valdés Hernández,
- Zoe Morris,
- Sally John,
- Paola G. Bronson,
- Elliot M. Tucker-Drob,
- John M. Starr,
- Mark E. Bastin,
- Joanna M. Wardlaw,
- Adam S. Butterworth,
- Ian J. Deary
Affiliations
- Sarah E. Harris
- Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh
- Simon R. Cox
- Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh
- Steven Bell
- UK Medical Research Council/British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Wort’s Causeway
- Riccardo E. Marioni
- Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh
- Bram P. Prins
- UK Medical Research Council/British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Wort’s Causeway
- Alison Pattie
- Department of Psychology, University of Edinburgh
- Janie Corley
- Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh
- Susana Muñoz Maniega
- Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh
- Maria Valdés Hernández
- Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh
- Zoe Morris
- Brain Research Imaging Centre, Neuroimaging Sciences, The University of Edinburgh, Chancellor’s Building
- Sally John
- Translational Biology, Biogen
- Paola G. Bronson
- Translational Biology, Biogen
- Elliot M. Tucker-Drob
- Department of Psychology, University of Texas
- John M. Starr
- Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh
- Mark E. Bastin
- Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh
- Joanna M. Wardlaw
- Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh
- Adam S. Butterworth
- UK Medical Research Council/British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Wort’s Causeway
- Ian J. Deary
- Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh
- DOI
- https://doi.org/10.1038/s41467-019-14161-7
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 12
Abstract
Late-life cognitive dysfunction is common, but the biological substrates are largely unknown. Here, the authors examined a panel of 90 neurology-related protein biomarkers and show that plasma levels of 22 of these proteins are associated with general fluid cognitive ability in later life.
