Clinical and Applied Thrombosis/Hemostasis (Feb 2024)

Super Formula for Soluble C-Type Lectin-Like Receptor 2 × D-Dimer in Patients With Acute Cerebral Infarction

  • Toshitaka Kamon MD,
  • Hideo Wada MD, PhD,
  • Shotaro Horie MD,
  • Tomoya Inaba MD,
  • Karin Okamoto MD,
  • Katsuya Shiraki MD, PhD,
  • Yuhuko Ichikawa,
  • Minoru Ezaki,
  • Motomu Shimaoka MD, PhD,
  • Akisato Nishigaki MD,
  • Akihiro Shindo MD, PhD,
  • Hideto Shimpo MD, PhD,
  • Nobuo Ito MD

DOI
https://doi.org/10.1177/10760296241232858
Journal volume & issue
Vol. 30

Abstract

Read online

Acute cerebral infarction (ACI) includes atherosclerotic and cardiogenic ACI and involves a thrombotic state, requiring antithrombotic treatment. However, the thrombotic state in ACI cannot be evaluated using routine hemostatic examinations. Plasma soluble C-type lectin-like receptor 2 (sCLEC-2) and D-dimer levels were measured in patients with ACI. Plasma sCLEC-2 and D-dimer levels were significantly higher in patients with ACI than in those without it. The sCLEC-2 × D-dimer formula was significantly higher in patients with ACI than in those without it. A receiver operating characteristic curve showed a high sensitivity, area under the curve, and odds for diagnosing ACI in the sCLEC-2 × D-dimer formula. Although the sCLEC-2 and D-dimer levels were useful for the differential diagnosis between cardiogenic and atherosclerotic ACI, the sCLEC-2 × D-dimer formula was not useful. sCLEC2 and D-dimer levels are useful for the diagnosis of ACI and the sCLEC2 × D-dimer formula can enhance the diagnostic ability of ACI, and sCLEC2 and D-dimer levels may be useful for differentiating between atherosclerotic and cardioembolic ACI.