Timbe (<i>Acaciella angustissima</i>) Pods Extracts Reduce the Levels of Glucose, Insulin and Improved Physiological Parameters, Hypolipidemic Effect, Oxidative Stress and Renal Damage in Streptozotocin-Induced Diabetic Rats
Adriana Jheny Rodríguez-Méndez,
Wendy Carmen-Sandoval,
Consuelo Lomas-Soria,
Ramón G. Guevara-González,
Rosalía Reynoso-Camacho,
María Elena Villagran-Herrera,
Luis Salazar-Olivo,
Irineo Torres-Pacheco,
Ana A. Feregrino-Pérez
Affiliations
Adriana Jheny Rodríguez-Méndez
Facultad de Medicina, Universidad Autónoma de Querétaro, Clavel No 200, Col. Prados de la Capilla, 76176 Querétaro, Mexico
Wendy Carmen-Sandoval
Facultad de Medicina, Universidad Autónoma de Querétaro, Clavel No 200, Col. Prados de la Capilla, 76176 Querétaro, Mexico
Consuelo Lomas-Soria
División de Estudios de Posgrado, C.A. Ingeniería de Biosistemas. Facultad de Ingeniería. Universidad Autónoma de Querétaro, C. U. Cerro de las Campanas, S/N, 76010 Querétaro, Mexico
Ramón G. Guevara-González
División de Estudios de Posgrado, C.A. Ingeniería de Biosistemas. Facultad de Ingeniería. Universidad Autónoma de Querétaro, C. U. Cerro de las Campanas, S/N, 76010 Querétaro, Mexico
Rosalía Reynoso-Camacho
Departamento de Investigación y Posgrado en Alimentos, PROPAC, Facultad de Química, Universidad Autónoma de Querétaro, C. U. Cerro de las Campanas, S/N, 76010 Querétaro, Mexico
María Elena Villagran-Herrera
Facultad de Medicina, Universidad Autónoma de Querétaro, Clavel No 200, Col. Prados de la Capilla, 76176 Querétaro, Mexico
Luis Salazar-Olivo
Instituto Potosino de Investigación Científica y Tecnológica, IPICYT, camino a la presa san José 2055, col. Lomas 4 sección, 78216, San Luis Potosí, Mexico
Irineo Torres-Pacheco
División de Estudios de Posgrado, C.A. Ingeniería de Biosistemas. Facultad de Ingeniería. Universidad Autónoma de Querétaro, C. U. Cerro de las Campanas, S/N, 76010 Querétaro, Mexico
Ana A. Feregrino-Pérez
División de Estudios de Posgrado, C.A. Ingeniería de Biosistemas. Facultad de Ingeniería. Universidad Autónoma de Querétaro, C. U. Cerro de las Campanas, S/N, 76010 Querétaro, Mexico
In Mexico one in 14 deaths are caused by diabetes mellitus (DM) or by the macro and microvascular disorders derived from it. A continuous hyperglycemic state is characteristic of DM, resulting from a sustained state of insulin resistance and/or a dysfunction of β-pancreatic cells. Acaciella angustissima is a little studied species showing a significant antioxidant activity that can be used as treatment of this disease or preventive against the complications. The objective of this study was to explore the effect of oral administration of A. angustissima methanol extract on physiological parameters of streptozotocin-induced diabetic rats. The results indicated a significant reduction in blood glucose levels, an increase in serum insulin concentration, a decrease in lipid levels and an improvement in the parameters of kidney damage by applying a concentration of 100 mg/Kg B.W. However, glucose uptake activity was not observed in the adipocyte assay. Moreover, the extract of A. angustissima displayed potential for the complementary treatment of diabetes and its complications likely due to the presence of bioactive compounds such as protocatechuic acid. This study demonstrated that methanol extract of Acacciella angustissima has an antidiabetic effect by reducing the levels of glucose, insulin and improved physiological parameters, hypolipidemic effect, oxidative stress and renal damage in diabetic rats.
