Nutrients (Apr 2019)

Sleep Duration is Inversely Associated with Serum Uric Acid Concentrations and Uric Acid to Creatinine Ratio in an Elderly Mediterranean Population at High Cardiovascular Risk

  • Christopher Papandreou,
  • Nancy Babio,
  • Andrés Díaz-López,
  • Miguel Á. Martínez-González,
  • Nerea Becerra-Tomas,
  • Dolores Corella,
  • Helmut Schröder,
  • Dora Romaguera,
  • Jesús Vioque,
  • Ángel M. Alonso-Gómez,
  • Julia Wärnberg,
  • Alfredo J. Martínez,
  • Lluís Serra-Majem,
  • Ramon Estruch,
  • Araceli Muñoz-Garach,
  • José Lapetra,
  • Xavier Pintó,
  • Josep A. Tur,
  • Antonio Garcia-Rios,
  • Aurora Bueno-Cavanillas,
  • Miguel Delgado-Rodríguez,
  • Pilar Matía-Martín,
  • Lidia Daimiel,
  • Vicente Martín-Sánchez,
  • Josep Vidal,
  • Clotilde Vázquez,
  • Emilio Ros,
  • Miguel Ruiz-Canela,
  • Mónica Bulló,
  • Jose V. Sorli,
  • Mireia Quifer,
  • Antoni Colom,
  • Alejandro Oncina-Canovas,
  • Lucas Tojal-Sierra,
  • Javier Barón-López,
  • Napoleón Pérez-Farinós,
  • Itziar Abete,
  • Almudena Sanchez-Villegas,
  • Rosa Casas,
  • José C. Fernández-Garcia,
  • José M. Santos-Lozano,
  • Emili Corbella,
  • Maria del M. Bibiloni,
  • Javier Diez-Espino,
  • Eva M. Asensio,
  • Laura Torras,
  • Marga Morey,
  • Laura Compañ-Gabucio,
  • Itziar Salaverria-Lete,
  • Juan C. Cenoz-Osinaga,
  • Olga Castañer,
  • Jordi Salas-Salvadó

DOI
https://doi.org/10.3390/nu11040761
Journal volume & issue
Vol. 11, no. 4
p. 761

Abstract

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The aim of the study was to evaluate sleep duration and sleep variability in relation to serum uric acid (SUA) concentrations and SUA to creatinine ratio. This is a cross-sectional analysis of baseline data from 1842 elderly participants with overweight/obesity and metabolic syndrome in the (Prevención con Dieta Mediterránea) PREDIMED-Plus trial. Accelerometry-derived sleep duration and sleep variability were measured. Linear regression models were fitted to examine the aforementioned associations. A 1 hour/night increment in sleep duration was inversely associated with SUA concentrations (β = −0.07, p = 0.047). Further adjustment for leukocytes attenuated this association (p = 0.050). Each 1-hour increment in sleep duration was inversely associated with SUA to creatinine ratio (β = −0.15, p = 0.001). The findings of this study suggest that longer sleep duration is associated with lower SUA concentrations and lower SUA to creatinine ratio.

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