Can Hematological Parameters Indicate Possible Inflammatory Mechanisms in Children with Intellectual Disability?

Abstract

Objective: This study aims to interpret the hematological parameters of children with the intellectual disability and to show the relationship between hematological parameters and possible inflammatory mechanisms of intellectual disability. Materials and Methods: In this study, 50 children with the intellectual disability (32 males, 18 females) and 40 healthy individuals (25 males, 15 females) were retrospectively screened. Lymphocyte and platelet count, white blood cell count, neutrophil, platelet to lymphocyte ratio (PLR), neutrophil to lymphocyte ratio (NLR), red cell distribution width (RDW) and mean platelet volume (MPV) were recorded for both groups and compared. Results: Neutrophil to lymphocyte ratio and neutrophil counts in the intellectual disability group were elevated than control. Mean platelet volume in the intellectual disability group was higher than the control and red cell distribution width in children with the intellectual disability was elevated than control. We did not detect any statistical difference in neutrophil to lymphocyte ratio between the groups with or without inborn error of metabolism. Conclusion: The findings obtained in this study suggest that we can use mean platelet volume, neutrophil to lymphocyte ratio and red cell distribution width as inflammatory markers for the intellectual disability of children.

Keywords

• children
• intellectual disability
• inflammation