Nature Communications (Sep 2021)

A concise access to bridged [2,2,1] bicyclic lactones with a quaternary stereocenter via stereospecific hydroformylation

  • Shuailong Li,
  • Zhuangxing Li,
  • Mingzheng Li,
  • Lin He,
  • Xumu Zhang,
  • Hui Lv

DOI
https://doi.org/10.1038/s41467-021-25569-5
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 9

Abstract

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Enantiomeric bridged [2,2,1] bicyclic lactone skeletons and their ring-opening products are important scaffolds widely occurring in both pharmaceutics and biology active compounds. Here the authors show an efficient method for enantioselective construction of these compounds bearing a quaternary stereocenter via Rh-catalyzed asymmetric hydroformylation/intramolecular cyclization/ pyridinium chlorochromate oxidation.