The correlation between serum cholesterol, asthma control and therapeutic step in children with asthma and aero allergenic sensitization

Abstract

Asthma is a heterogeneous disease characterized by chronic inflammation of the airways. Cholesterol is a pro-inflammatory factor linked in some studies to asthma inflammation. A prospective study has been started between January 2016 and September 2018 including 100 children aged 5 to 18 years old, diagnosed with allergic asthma and aero allergenic sensitization, evaluated and monitored in “Dr. Victor Gomoiu” Clinical Children’s Hospital. All patients enrolled in the study were monitored for the level of cholesterol, the therapeutic step and the degree of asthma control. The objective of the study was to assess the correlation between serum cholesterol and asthma control and between serum cholesterol and the step of controller treatment (as marker of asthma severity). Conclusions. In the studied group, patients in the categories of partially controlled and uncontrolled asthma were in a higher percentage with higher values of serum cholesterol compared with those with controlled asthma; the children registered in the categories of moderate and severe asthma were in a higher percentage with total serum cholesterol increased compared to those with mild asthma.

Keywords

• asthma
• control
• cholesterol
• controller treatment