Ratio of Mitral Peak Velocity of Early Filling to Early Diastolic Mitral Annular Velocity is More Sensitive than the Ratio of Mitral Peak Velocity of Early Filling to Mitral Peak Velocity of Late Filling in Detection of Left Ventricular Diastolic Dysfunction in Systemic Lupus Erythematous

Abstract

Background: SLE linked to cardiovascular issues, including myocarditis, valve diseases, and conduction abnormalities. E/A ratio for LV diastolic function assessment has limitations. E/E' ratio offers promise as an alternative, less affected by preload changes. Conventional echocardiography's role in evaluating diastolic function and related factors unclear. Objectives: A study compared the sensitivity of two ratios to detect LV diastolic dysfunction in patients with SLE: E/A ratio and E/ É ratio. Patients and Methods: Transthoracic echocardiography was conducted on a group of 100 patients with systemic lupus erythematosus (SLE) who did not have heart failure or angina symptoms. The results were then compared to a control group of 40 individuals who were matched in terms of age and sex. Myocardial tissue peak velocities at the lateral and septal angles of the mitral annulus were measured using conventional 2D echocardiography and pulsed wave (PW) tissue Doppler echocardiography. Results: In SLE cases, Mitral E velocity didn't significantly differ from controls, while A velocity showed a notable increase. E/A ratio remained similar between cases and controls, although cases exhibited a higher frequency of E/A ratio 8 and>15. Lateral E velocity and E/E ratio didn't significantly differ between the two groups, yet cases displayed a higher frequency of ratios >8. Conclusions: The E/E' ratio is more responsive than the E/A ratio in identifying left ventricular diastolic dysfunction in individuals with systemic lupus erythematosus (SLE).

Keywords

• systemic lupus erythematosus tissue doppler imaging
• left ventricle diastolic dysfunction