Archives of Endocrinology and Metabolism (Apr 2019)

Paraoxonase 1 serum activity in women: the effects of menopause, the C(-107)T polymorphism and food intake

  • Mauren Castro Ritta,
  • Aline Marques Baldez,
  • Isabel Oliveira de Oliveira,
  • Driele Neske Garcia,
  • Paola Spiering Souza,
  • Kelvin Ruan da Silva Andrade,
  • Sandra Costa Valle,
  • Simone Pieniz,
  • Carlos Castilho Barros,
  • Michal M. Masternak,
  • Augusto Schneider

DOI
https://doi.org/10.20945/2359-3997000000130
Journal volume & issue
no. 0

Abstract

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ABSTRACT Objective The aims of this study were to investigate changes in serum paraoxonase 1 (PON1) activity in women at the pre and postmenopausal stages and its association with the PON1 C(-107)T polymorphism and food intake profile. Subjects and methods A cross-sectional study with female patients aged between 35 and 59 years old was conducted. Women were divided into two groups: premenopausal (n = 40) and postmenopausal (n = 36). Women enrolled in the study had serum PON1, total cholesterol, HDL, LDL, glucose and HbA1c, as well as the BMI measured. Additionally, women were genotyped for the PON1 T(-107)C polymorphism and the food intake profile was obtained through interview. Results Glucose (p = 0.03), HbA1c (p = 0.002) and total cholesterol (p = 0.002)concentrations were higher in post than premenopausal women, however PON1 activity was not different (p > 0.05). Carriers of the C allele had higher PON1 activity (CC: 88.9 ± 6.5 U/mL and CT: 79.9 ± 4.7 U/mL) than women of the TT genotype (66.6 ± 5.9 U/mL) (p < 0.05). However, the model predicting PON1 activity was slightly better when genotype, total fat and cholesterol content in the diet were all included. Conclusion In sum, we observed that the PON1 C(-107)T genotype was the major regulator of PON1 activity, and menopause had no effect on PON1 activity. The lipid and glycemic profile were altered in postmenopausal women.

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