Distribution and Antimicrobial Resistance Patterns of Urinary Tract Infection in Southern Iran

Abstract

Background: Urinary tract infection (UTI) known as one of the most common diseases in the world. In order to apply the most appropriate antibiotics in the UTI therapy, studies on the vicinity of the epidemiology of common bacterial agents and determining their antibiotic resistance patterns are essential for physicians in different areas. In this study, the distribution and antimicrobial resistance patterns of urinary tract infection in southern Iran was verified. Methods: 511 suspected patients to UTIs referred to Fasa hospitals, south of Iran, were studied. The frequency of isolated bacteria and their resistance to common antibiotics in the UTIs therapy were investigated. Results: Out of 497 patients with bacterial UTIs, 8 types of bacterial species were isolated. The main isolated bacteria from both males and females was Escherichia coli (88.6%). Also, high rate of antibiotic resistance was shown in males rather than females. The highest antibiotic resistance of E. coli was found to nalidixic acid in men (86.8%) and the lowest antibiotic resistance was referred to ciprofloxacin in women (38.1%). Most susceptible cases to E. coli was detected for ciprofloxacin antibiotic (52.2% in women and 45.7% in men). Surprisingly, high antibiotic resistance was also observed in children aged 1 year or less. Conclusion: The high resistance of the first-generation fluoroquinolones (nalidixic acid) in UTIs treatment, seem to be not logical, whilst, the second-generation fluoroquinolone (ciprofloxacin) is nearly still recommended in Fasa region.

Keywords

• Urinary tract infection
• Antibiotic resistance
• Uropathogens
• Iran