Nature Communications (Oct 2022)
Long-term whole blood DNA preservation by cost-efficient cryosilicification
- Liang Zhou,
- Qi Lei,
- Jimin Guo,
- Yuanyuan Gao,
- Jianjun Shi,
- Hong Yu,
- Wenxiang Yin,
- Jiangfan Cao,
- Botao Xiao,
- Jacopo Andreo,
- Romy Ettlinger,
- C. Jeffrey Brinker,
- Stefan Wuttke,
- Wei Zhu
Affiliations
- Liang Zhou
- MOE International Joint Research Laboratory on Synthetic Biology and Medicines, School of Biology and Biological Engineering, South China University of Technology
- Qi Lei
- MOE International Joint Research Laboratory on Synthetic Biology and Medicines, School of Biology and Biological Engineering, South China University of Technology
- Jimin Guo
- Center for Micro-Engineered Materials and the Department of Chemical and Biological Engineering, The University of New Mexico
- Yuanyuan Gao
- MOE International Joint Research Laboratory on Synthetic Biology and Medicines, School of Biology and Biological Engineering, South China University of Technology
- Jianjun Shi
- Science and Technology on Advanced Functional Composites Technology, Aerospace Research Institute of Materials & Processing Technology
- Hong Yu
- MOE International Joint Research Laboratory on Synthetic Biology and Medicines, School of Biology and Biological Engineering, South China University of Technology
- Wenxiang Yin
- MOE International Joint Research Laboratory on Synthetic Biology and Medicines, School of Biology and Biological Engineering, South China University of Technology
- Jiangfan Cao
- MOE International Joint Research Laboratory on Synthetic Biology and Medicines, School of Biology and Biological Engineering, South China University of Technology
- Botao Xiao
- MOE International Joint Research Laboratory on Synthetic Biology and Medicines, School of Biology and Biological Engineering, South China University of Technology
- Jacopo Andreo
- BCMaterials, Basque Center for Materials, UPV/EHU Science Park
- Romy Ettlinger
- School of Chemistry, University of St. Andrews
- C. Jeffrey Brinker
- Center for Micro-Engineered Materials and the Department of Chemical and Biological Engineering, The University of New Mexico
- Stefan Wuttke
- BCMaterials, Basque Center for Materials, UPV/EHU Science Park
- Wei Zhu
- MOE International Joint Research Laboratory on Synthetic Biology and Medicines, School of Biology and Biological Engineering, South China University of Technology
- DOI
- https://doi.org/10.1038/s41467-022-33759-y
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
Cost-effective methods for long-term storage of DNA are desired. Here the authors present a method for in situ cryosilicification of whole blood cells, allowing long-term and room temperature preservation of genomic information for only approximately $0.5 per sample.
