Stored blood has compromised oxygen unloading kinetics that can be normalized with rejuvenation and predicted from corpuscular side-scatter

• Killian Donovan,
• Athinoula Meli,
• Francesca Cendali,
• Kyung Chan Park,
• Rebecca Cardigan,
• Simon Stanworth,
• Stuart McKechnie,
• Angelo D’Alessandro,
• Peter A. Smethurst,
• Pawel Swietach

Affiliations

Killian Donovan

Department of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, OX1 3PT, Oxford

Athinoula Meli

Component Development Laboratory, NHS Blood and Transplant, Cambridge

Francesca Cendali

Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO

Kyung Chan Park

Department of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, OX1 3PT, Oxford

Rebecca Cardigan

Component Development Laboratory, NHS Blood and Transplant, Cambridge, United Kingdom; Department of Haematology, University of Cambridge, Cambridge

Simon Stanworth

Transfusion Medicine, NHS Blood and Transplant, Oxford, England; Department of Haematology, Oxford University Hospitals NHS Foundation Trust, Oxford, England; Radcliffe Department of Medicine, University of Oxford, and Oxford BRC Haematology Theme

Stuart McKechnie

Adult Intensive Care Unit, John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford

Angelo D’Alessandro

Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO

Peter A. Smethurst

Component Development Laboratory, NHS Blood and Transplant, Cambridge

Pawel Swietach

Department of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, OX1 3PT, Oxford