Сахарный диабет (Mar 2010)

The role of apoptosis in pathogenesis of type 1 diabetes mellitus

  • Elena Vladimirovna Pekareva,
  • Tatiana Vasil'evna Nikonova,
  • Olga Mikhailovna Smirnova

DOI
https://doi.org/10.14341/2072-0351-6016
Journal volume & issue
Vol. 13, no. 1
pp. 45 – 49

Abstract

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Type 1 diabetes mellitus (DM1) is known to be associated with progressive destruction of pancreatic beta-cells. Apoptosis plays the key role in this destructiveprocess. The paper focuses on major mechanisms underlying activation of beta-cell apoptosis and its role in regulation of immune processes inpatients with DM1.

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