Journal of Epidemiology (Dec 2021)

Study Profile of the Japan Multi-institutional Collaborative Cohort (J-MICC) Study

  • Kenji Takeuchi,
  • Mariko Naito,
  • Sayo Kawai,
  • Mineko Tsukamoto,
  • Yuka Kadomatsu,
  • Yoko Kubo,
  • Rieko Okada,
  • Mako Nagayoshi,
  • Takashi Tamura,
  • Asahi Hishida,
  • Masahiro Nakatochi,
  • Tae Sasakabe,
  • Shuji Hashimoto,
  • Hidetaka Eguchi,
  • Yukihide Momozawa,
  • Hiroaki Ikezaki,
  • Masayuki Murata,
  • Norihiro Furusyo,
  • Keitaro Tanaka,
  • Megumi Hara,
  • Yuichiro Nishida,
  • Keitaro Matsuo,
  • Hidemi Ito,
  • Isao Oze,
  • Haruo Mikami,
  • Yohko Nakamura,
  • Miho Kusakabe,
  • Toshiro Takezaki,
  • Rie Ibusuki,
  • Ippei Shimoshikiryo,
  • Sadao Suzuki,
  • Takeshi Nishiyama,
  • Miki Watanabe,
  • Teruhide Koyama,
  • Etsuko Ozaki,
  • Isao Watanabe,
  • Kiyonori Kuriki,
  • Yoshikuni Kita,
  • Hirotsugu Ueshima,
  • Kenji Matsui,
  • Kokichi Arisawa,
  • Hirokazu Uemura,
  • Sakurako Katsuura-Kamano,
  • Sho Nakamura,
  • Hiroto Narimatsu,
  • Nobuyuki Hamajima,
  • Hideo Tanaka,
  • Kenji Wakai

DOI
https://doi.org/10.2188/jea.JE20200147
Journal volume & issue
Vol. 31, no. 12
pp. 660 – 668

Abstract

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Background: The Japan Multi-institutional Collaborative Cohort (J-MICC) study was launched in 2005 to examine gene–environment interactions in lifestyle-related diseases, including cancers, among the Japanese. This report describes the study design and baseline profile of the study participants. Methods: The participants of the J-MICC Study were individuals aged 35 to 69 years enrolled from respondents to study announcements in specified regions, inhabitants attending health checkup examinations provided by local governments, visitors at health checkup centers, and first-visit patients at a cancer hospital in Japan. At the time of the baseline survey, from 2005 to 2014, we obtained comprehensive information regarding demographics, education, alcohol consumption, smoking, sleeping, exercise, food intake frequency, medication and supplement use, personal and family disease history, psychological stress, and female reproductive history and collected peripheral blood samples. Results: The baseline survey included 92,610 adults (mean age: 55.2 [standard deviation, 9.4] years, 44.1% men) from 14 study regions in 12 prefectures. The participation rate was 33.5%, with participation ranging from 19.7% to 69.8% in different study regions. The largest number of participants was in the age groups of 65–69 years for men and 60–64 years for women. There were differences in body mass index, educational attainment, alcohol consumption, smoking, and sleep duration between men and women. Conclusions: The J-MICC Study collected lifestyle and clinical data and biospecimens from over 90,000 participants. This cohort is expected to be a valuable resource for the national and international scientific community in providing evidence to support longer healthy lives.

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