Computational mass spectrometry accelerates C = C position-resolved untargeted lipidomics using oxygen attachment dissociation

Abstract

Mass spectrometry is a powerful approach for untargeted lipidomics, however, the unambiguous determination of double bond positions remains challenging. Here, the authors present an approach for double bond position-resolved untargeted lipidomics using a combination of oxygen attachment dissociation and computational mass spectrometry to accurately annotate the biologically relevant lipidome.