Nature Communications (Oct 2018)
Testicular endothelial cells are a critical population in the germline stem cell niche
- Dong Ha Bhang,
- Bang-Jin Kim,
- Byung Gak Kim,
- Keri Schadler,
- Kwan-Hyuck Baek,
- Yong Hee Kim,
- Wayland Hsiao,
- Bi-Sen Ding,
- Shahin Rafii,
- Mitchell J. Weiss,
- Stella T. Chou,
- Thomas F. Kolon,
- Jill P. Ginsberg,
- Buom-Yong Ryu,
- Sandra Ryeom
Affiliations
- Dong Ha Bhang
- Department of Cancer Biology, Perelman School of Medicine at the University of Pennsylvania
- Bang-Jin Kim
- Department of Cancer Biology, Perelman School of Medicine at the University of Pennsylvania
- Byung Gak Kim
- Department of Cancer Biology, Perelman School of Medicine at the University of Pennsylvania
- Keri Schadler
- Department of Cancer Biology, Perelman School of Medicine at the University of Pennsylvania
- Kwan-Hyuck Baek
- Department of Molecular and Cellular Biology, Sungkyunkwan University School of Medicine
- Yong Hee Kim
- Department of Animal Science and Technology, Chung-Ang University
- Wayland Hsiao
- Ansary Stem Cell Institute, Howard Hughes Medical Institute, Department of Genetic Medicine, Weill Cornell Medical College
- Bi-Sen Ding
- Ansary Stem Cell Institute, Howard Hughes Medical Institute, Department of Genetic Medicine, Weill Cornell Medical College
- Shahin Rafii
- Ansary Stem Cell Institute, Howard Hughes Medical Institute, Department of Genetic Medicine, Weill Cornell Medical College
- Mitchell J. Weiss
- Department of Hematology, St. Jude Children’s Research Hospital
- Stella T. Chou
- Division of Hematology, The Children’s Hospital of Philadelphia
- Thomas F. Kolon
- Division of Urology, Children’s Hospital of Philadelphia, Department of Surgery (Urology), Perelman School of Medicine at the University of Pennsylvania
- Jill P. Ginsberg
- Division of Oncology, Children’s Hospital of Philadelphia, Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania,
- Buom-Yong Ryu
- Department of Animal Science and Technology, Chung-Ang University
- Sandra Ryeom
- Department of Cancer Biology, Perelman School of Medicine at the University of Pennsylvania
- DOI
- https://doi.org/10.1038/s41467-018-06881-z
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 16
Abstract
Self-renewal of spermatogonial stem cells (SSC) is necessary for spermatogenesis and male fertility. Here the authors identify testicular endothelial cells (TECs) as a source of 5 key growth factors for self-renewal and expansion of human and mouse SSCs.
