Nature Communications (Jan 2020)
BCL9 provides multi-cellular communication properties in colorectal cancer by interacting with paraspeckle proteins
- Meng Jiang,
- Yue Kang,
- Tomasz Sewastianik,
- Jiao Wang,
- Helen Tanton,
- Keith Alder,
- Peter Dennis,
- Yu Xin,
- Zhongqiu Wang,
- Ruiyang Liu,
- Mengyun Zhang,
- Ying Huang,
- Massimo Loda,
- Amitabh Srivastava,
- Runsheng Chen,
- Ming Liu,
- Ruben D. Carrasco
Affiliations
- Meng Jiang
- Department of Oncologic Pathology, Dana-Farber Cancer Institute, Harvard Medical School
- Yue Kang
- Department of Oncologic Pathology, Dana-Farber Cancer Institute, Harvard Medical School
- Tomasz Sewastianik
- Department of Oncologic Pathology, Dana-Farber Cancer Institute, Harvard Medical School
- Jiao Wang
- Department of Oncologic Pathology, Dana-Farber Cancer Institute, Harvard Medical School
- Helen Tanton
- Department of Oncologic Pathology, Dana-Farber Cancer Institute, Harvard Medical School
- Keith Alder
- Department of Oncologic Pathology, Dana-Farber Cancer Institute, Harvard Medical School
- Peter Dennis
- Department of Oncologic Pathology, Dana-Farber Cancer Institute, Harvard Medical School
- Yu Xin
- Department of Oncologic Pathology, Dana-Farber Cancer Institute, Harvard Medical School
- Zhongqiu Wang
- Department of Oncologic Pathology, Dana-Farber Cancer Institute, Harvard Medical School
- Ruiyang Liu
- Department of Oncologic Pathology, Dana-Farber Cancer Institute, Harvard Medical School
- Mengyun Zhang
- Department of Oncologic Pathology, Dana-Farber Cancer Institute, Harvard Medical School
- Ying Huang
- Department of Oncologic Pathology, Dana-Farber Cancer Institute, Harvard Medical School
- Massimo Loda
- Department of Oncologic Pathology, Dana-Farber Cancer Institute, Harvard Medical School
- Amitabh Srivastava
- Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School
- Runsheng Chen
- Key Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences
- Ming Liu
- Department of General Surgery, Fourth Affiliated Hospital of Harbin Medical University, Harbin Medical University
- Ruben D. Carrasco
- Department of Oncologic Pathology, Dana-Farber Cancer Institute, Harvard Medical School
- DOI
- https://doi.org/10.1038/s41467-019-13842-7
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 16
Abstract
BCL9 is an activator of oncogenic Wnt/β-catenin. Here, the authors show a β-catenin independent function of BCL9 in a subtype of colorectal cancers, where it interacts with paraspeckle proteins to enhance the mRNA stability of calcium signalling and neural associated genes to promote communication with tumour cells and its microenvironment.
