Nature Communications (Feb 2021)

The HIF-1α antisense long non-coding RNA drives a positive feedback loop of HIF-1α mediated transactivation and glycolysis

  • Fang Zheng,
  • Jianing Chen,
  • Xiaoqian Zhang,
  • Zifeng Wang,
  • Jiewen Chen,
  • Xiaorong Lin,
  • Hongyan Huang,
  • Wenkui Fu,
  • Jing Liang,
  • Wei Wu,
  • Bo Li,
  • Herui Yao,
  • Hai Hu,
  • Erwei Song

DOI
https://doi.org/10.1038/s41467-021-21535-3
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 20

Abstract

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HIF1alpha is reported to drive tumourigenesis through activating glycolysis. Here, the authors show that HIFAL, the HIF1alpha antisense long non-coding RNA, and HIF1alpha form a positive feed-forward loop which is essential for HIF1a-mediated metabolic reprogramming and oncogenic role.