Nature Communications (Jan 2021)
High-fidelity DNA ligation enforces accurate Okazaki fragment maturation during DNA replication
Abstract
DNA ligase 1 (LIG1) finalizes eukaryotic nuclear DNA synthesis by sealing Okazaki fragments using DNA end-joining reactions. Here the authors, by studying an engineered low-fidelity LIG1, reveal that LIG1 is a highly accurate DNA ligase in vivo.