Nature Communications (Jan 2023)
Effect of β2-agonist treatment on insulin-stimulated peripheral glucose disposal in healthy men in a randomised placebo-controlled trial
- Sten M. M. van Beek,
- Yvonne M. H. Bruls,
- Froukje Vanweert,
- Ciarán E. Fealy,
- Niels J. Connell,
- Gert Schaart,
- Esther Moonen-Kornips,
- Johanna A. Jörgensen,
- Frédéric M. Vaz,
- Ellen T. H. C. Smeets,
- Peter J. Joris,
- Anne Gemmink,
- Riekelt H. Houtkooper,
- Matthijs K. C. Hesselink,
- Tore Bengtsson,
- Bas Havekes,
- Patrick Schrauwen,
- Joris Hoeks
Affiliations
- Sten M. M. van Beek
- Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University
- Yvonne M. H. Bruls
- Department of Radiology and Nuclear Medicine, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+
- Froukje Vanweert
- Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University
- Ciarán E. Fealy
- Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University
- Niels J. Connell
- Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University
- Gert Schaart
- Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University
- Esther Moonen-Kornips
- Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University
- Johanna A. Jörgensen
- Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University
- Frédéric M. Vaz
- Laboratory Genetic Metabolic Diseases, Amsterdam UMC location University of Amsterdam
- Ellen T. H. C. Smeets
- Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University
- Peter J. Joris
- Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University
- Anne Gemmink
- Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University
- Riekelt H. Houtkooper
- Laboratory Genetic Metabolic Diseases, Amsterdam UMC location University of Amsterdam
- Matthijs K. C. Hesselink
- Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University
- Tore Bengtsson
- Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University
- Bas Havekes
- Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University
- Patrick Schrauwen
- Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University
- Joris Hoeks
- Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University
- DOI
- https://doi.org/10.1038/s41467-023-35798-5
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 15
Abstract
β2-agonist treatment improves skeletal muscle glucose uptake and whole-body glucose homeostasis in rodents. Here the authors report that two-weeks of treatment with the β2-agonist clenbuterol improves insulin-stimulated glucose disposal in healthy young men in a double-blinded, randomized cross-over trial.
