Nature Communications (Aug 2022)
Transcontinental spread and evolution of Mycobacterium tuberculosis W148 European/Russian clade toward extensively drug resistant tuberculosis
- Matthias Merker,
- Jean-Philippe Rasigade,
- Maxime Barbier,
- Helen Cox,
- Silke Feuerriegel,
- Thomas A. Kohl,
- Egor Shitikov,
- Kadri Klaos,
- Cyril Gaudin,
- Rudy Antoine,
- Roland Diel,
- Sonia Borrell,
- Sebastien Gagneux,
- Vladyslav Nikolayevskyy,
- Sönke Andres,
- Valeriu Crudu,
- Philip Supply,
- Stefan Niemann,
- Thierry Wirth
Affiliations
- Matthias Merker
- Molecular and Experimental Mycobacteriology, Research Center Borstel
- Jean-Philippe Rasigade
- EPHE, PSL University
- Maxime Barbier
- EPHE, PSL University
- Helen Cox
- Division of Medical Microbiology and Institute of Infectious Disease and Molecular Medicine, University of Cape Town
- Silke Feuerriegel
- Molecular and Experimental Mycobacteriology, Research Center Borstel
- Thomas A. Kohl
- Molecular and Experimental Mycobacteriology, Research Center Borstel
- Egor Shitikov
- Federal Research and Clinical Centre of Physical-Chemical Medicine
- Kadri Klaos
- SA TUH United Laboratories, Mycobacteriology
- Cyril Gaudin
- Genoscreen
- Rudy Antoine
- Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 9017 - CIIL - Centre d’Infection et d’Immunité de Lille
- Roland Diel
- Institute for Epidemiology, Schleswig-Holstein University Hospital
- Sonia Borrell
- Swiss Tropical and Public Health Institute
- Sebastien Gagneux
- Swiss Tropical and Public Health Institute
- Vladyslav Nikolayevskyy
- Imperial College London
- Sönke Andres
- National and WHO Supranational Reference Center for Mycobacteria, Research Center Borstel
- Valeriu Crudu
- National TB Reference Laboratory, Institute of Phthisiopneumology
- Philip Supply
- Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 9017 - CIIL - Centre d’Infection et d’Immunité de Lille
- Stefan Niemann
- Molecular and Experimental Mycobacteriology, Research Center Borstel
- Thierry Wirth
- EPHE, PSL University
- DOI
- https://doi.org/10.1038/s41467-022-32455-1
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 11
Abstract
An outbreak of the multidrug-resistant Mycobacterium tuberculosis lineage W148 has spread widely across Russia, Central Asia and Europe. Here, the authors use whole genome sequences of ~700 isolates of this lineage collected over ~20 years to analyze its spread, evolution of drug resistance, and impact of compensatory mutations.
