Histopathological Studies on Chronic Gastritis Associated with Helicobacter pylori Infection from Rural Area of India

Abstract

Background: Helicobacter pylori infection has been implicated as a major cause of chronic gastritis. It has been categorized as class 1 carcinogen. Aim and Objectives: An attempt has been made to evaluate the incidence of H. pylori in patients with chronic gastritis and to find out histopathologic indicators of presence of H. pylori in chronic gastritis. Material and Methods: A total of 101 biopsies from patients with chronic gastritis were evaluated using H & E and Giemsa stains. Biopsies were histopathologically graded according to the 1994 Updated Sydney system. Results: Neutrophilic activity was noted in 78 (77.2%), lymphoid aggregates were noted in 23 (22.7%) and atrophy was noted in 17 (16.83%) biopsies. The mononuclear cell infiltrate grading was mild in 43, moderate in 47 and marked in 11 biopsies. H. pylori were found positive in 79 (78.2%) biopsies. Neutrophilic activity with chronic gastritis and H. pylori association was highly significant (p value - -12 4.826×10 ). Significant association of presence of lymphoid aggregate with chronic gastritis and H. pylori (p value-0.0095) was also noted. Conclusion: Cases with chronic gastritis associated with neutrophilic activity with presence of lymphoid aggregate suggest H. pylori infection. Institution of rational treatment based on accurate diagnosis and eradication of H. pylori significantly reduces use of acid suppression and the risk for development of gastric malignancies.

Keywords

• H. pylori
• Chronic Gastritis
• Histopathologic Examination