Nature Communications (Oct 2017)
A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction
- Michael R. Bowl,
- Michelle M. Simon,
- Neil J. Ingham,
- Simon Greenaway,
- Luis Santos,
- Heather Cater,
- Sarah Taylor,
- Jeremy Mason,
- Natalja Kurbatova,
- Selina Pearson,
- Lynette R. Bower,
- Dave A. Clary,
- Hamid Meziane,
- Patrick Reilly,
- Osamu Minowa,
- Lois Kelsey,
- The International Mouse Phenotyping Consortium,
- Glauco P. Tocchini-Valentini,
- Xiang Gao,
- Allan Bradley,
- William C. Skarnes,
- Mark Moore,
- Arthur L. Beaudet,
- Monica J. Justice,
- John Seavitt,
- Mary E. Dickinson,
- Wolfgang Wurst,
- Martin Hrabe de Angelis,
- Yann Herault,
- Shigeharu Wakana,
- Lauryl M. J. Nutter,
- Ann M. Flenniken,
- Colin McKerlie,
- Stephen A. Murray,
- Karen L. Svenson,
- Robert E. Braun,
- David B. West,
- K. C. Kent Lloyd,
- David J. Adams,
- Jacqui White,
- Natasha Karp,
- Paul Flicek,
- Damian Smedley,
- Terrence F. Meehan,
- Helen E. Parkinson,
- Lydia M. Teboul,
- Sara Wells,
- Karen P. Steel,
- Ann-Marie Mallon,
- Steve D. M. Brown
Affiliations
- Michael R. Bowl
- Medical Research Council Harwell Institute (Mammalian Genetics Unit and Mary Lyon Centre)
- Michelle M. Simon
- Medical Research Council Harwell Institute (Mammalian Genetics Unit and Mary Lyon Centre)
- Neil J. Ingham
- King’s College London
- Simon Greenaway
- Medical Research Council Harwell Institute (Mammalian Genetics Unit and Mary Lyon Centre)
- Luis Santos
- Medical Research Council Harwell Institute (Mammalian Genetics Unit and Mary Lyon Centre)
- Heather Cater
- Medical Research Council Harwell Institute (Mammalian Genetics Unit and Mary Lyon Centre)
- Sarah Taylor
- Medical Research Council Harwell Institute (Mammalian Genetics Unit and Mary Lyon Centre)
- Jeremy Mason
- European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus
- Natalja Kurbatova
- European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus
- Selina Pearson
- The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- Lynette R. Bower
- Mouse Biology Program, University of California
- Dave A. Clary
- Mouse Biology Program, University of California
- Hamid Meziane
- CELPHEDIA, PHENOMIN, Institut Clinique de la Souris (ICS)
- Patrick Reilly
- CELPHEDIA, PHENOMIN, Institut Clinique de la Souris (ICS)
- Osamu Minowa
- RIKEN BioResource Center
- Lois Kelsey
- The Centre for Phenogenomics
- The International Mouse Phenotyping Consortium
- Glauco P. Tocchini-Valentini
- Monterotondo Mouse Clinic, Italian National Research Council (CNR), Institute of Cell Biology and Neurobiology
- Xiang Gao
- SKL of Pharmaceutical Biotechnology and Model Animal Research Center, Collaborative Innovation Center for Genetics and Development, Nanjing Biomedical Research Institute, Nanjing University
- Allan Bradley
- The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- William C. Skarnes
- The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- Mark Moore
- IMPC
- Arthur L. Beaudet
- Department of Molecular and Human Genetics, Baylor College of Medicine
- Monica J. Justice
- The Centre for Phenogenomics
- John Seavitt
- Department of Molecular and Human Genetics, Baylor College of Medicine
- Mary E. Dickinson
- Department of Molecular Physiology and Biophysics, Baylor College of Medicine
- Wolfgang Wurst
- Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH
- Martin Hrabe de Angelis
- German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH
- Yann Herault
- CELPHEDIA, PHENOMIN, Institut Clinique de la Souris (ICS)
- Shigeharu Wakana
- RIKEN BioResource Center
- Lauryl M. J. Nutter
- The Centre for Phenogenomics
- Ann M. Flenniken
- The Centre for Phenogenomics
- Colin McKerlie
- The Centre for Phenogenomics
- Stephen A. Murray
- The Jackson Laboratory
- Karen L. Svenson
- The Jackson Laboratory
- Robert E. Braun
- The Jackson Laboratory
- David B. West
- Childrens’ Hospital Oakland Research Institute
- K. C. Kent Lloyd
- Mouse Biology Program, University of California
- David J. Adams
- The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- Jacqui White
- The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- Natasha Karp
- The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- Paul Flicek
- European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus
- Damian Smedley
- Queen Mary University of London
- Terrence F. Meehan
- European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus
- Helen E. Parkinson
- European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus
- Lydia M. Teboul
- Medical Research Council Harwell Institute (Mammalian Genetics Unit and Mary Lyon Centre)
- Sara Wells
- Medical Research Council Harwell Institute (Mammalian Genetics Unit and Mary Lyon Centre)
- Karen P. Steel
- King’s College London
- Ann-Marie Mallon
- Medical Research Council Harwell Institute (Mammalian Genetics Unit and Mary Lyon Centre)
- Steve D. M. Brown
- Medical Research Council Harwell Institute (Mammalian Genetics Unit and Mary Lyon Centre)
- DOI
- https://doi.org/10.1038/s41467-017-00595-4
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 11
Abstract
The full extent of the genetic basis for hearing impairment is unknown. Here, as part of the International Mouse Phenotyping Consortium, the authors perform a hearing loss screen in 3006 mouse knockout strains and identify 52 new candidate genes for genetic hearing loss.
