Nature Communications (Dec 2017)
Midbrain circuit regulation of individual alcohol drinking behaviors in mice
- Barbara Juarez,
- Carole Morel,
- Stacy M. Ku,
- Yutong Liu,
- Hongxing Zhang,
- Sarah Montgomery,
- Hilledna Gregoire,
- Efrain Ribeiro,
- Marshall Crumiller,
- Ciorana Roman-Ortiz,
- Jessica J. Walsh,
- Kelcy Jackson,
- Denise E. Croote,
- Yingbo Zhu,
- Song Zhang,
- Leandro F. Vendruscolo,
- Scott Edwards,
- Amanda Roberts,
- Georgia E. Hodes,
- Yongke Lu,
- Erin S. Calipari,
- Dipesh Chaudhury,
- Allyson K. Friedman,
- Ming-Hu Han
Affiliations
- Barbara Juarez
- Department of Pharmacological Sciences and Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai
- Carole Morel
- Department of Pharmacological Sciences and Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai
- Stacy M. Ku
- Department of Pharmacological Sciences and Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai
- Yutong Liu
- Department of Pharmacological Sciences and Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai
- Hongxing Zhang
- Department of Pharmacological Sciences and Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai
- Sarah Montgomery
- Department of Pharmacological Sciences and Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai
- Hilledna Gregoire
- Department of Pharmacological Sciences and Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai
- Efrain Ribeiro
- Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
- Marshall Crumiller
- Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
- Ciorana Roman-Ortiz
- Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
- Jessica J. Walsh
- Department of Pharmacological Sciences and Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai
- Kelcy Jackson
- Department of Pharmacological Sciences and Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai
- Denise E. Croote
- Department of Pharmacological Sciences and Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai
- Yingbo Zhu
- Department of Pharmacological Sciences and Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai
- Song Zhang
- Department of Pharmacological Sciences and Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai
- Leandro F. Vendruscolo
- Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health
- Scott Edwards
- Department of Physiology, Alcohol and Drug Abuse Center of Excellence, Neuroscience Center of Excellence, Louisiana State University Health Sciences Center
- Amanda Roberts
- Department of Molecular and Cellular Neuroscience, The Scripps Research Institute
- Georgia E. Hodes
- Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
- Yongke Lu
- Department of Medicine, Icahn School of Medicine at Mount Sinai
- Erin S. Calipari
- Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
- Dipesh Chaudhury
- Department of Pharmacological Sciences and Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai
- Allyson K. Friedman
- Department of Pharmacological Sciences and Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai
- Ming-Hu Han
- Department of Pharmacological Sciences and Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai
- DOI
- https://doi.org/10.1038/s41467-017-02365-8
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 15
Abstract
Mice exposed to a two-bottle alcohol choice paradigm can be divided into high and low drinking groups. Here, the authors show that stimulating VTA neurons to induce higher phasic activity patterns that are observed in low alcohol drinking mice, suppresses alcohol drinking in mice that are high alcohol drinking.
