Nature Communications (Jul 2022)
Microglia coordinate cellular interactions during spinal cord repair in mice
- Faith H. Brennan,
- Yang Li,
- Cankun Wang,
- Anjun Ma,
- Qi Guo,
- Yi Li,
- Nicole Pukos,
- Warren A. Campbell,
- Kristina G. Witcher,
- Zhen Guan,
- Kristina A. Kigerl,
- Jodie C. E. Hall,
- Jonathan P. Godbout,
- Andy J. Fischer,
- Dana M. McTigue,
- Zhigang He,
- Qin Ma,
- Phillip G. Popovich
Affiliations
- Faith H. Brennan
- Department of Neuroscience, The Ohio State University Wexner Medical Center
- Yang Li
- Department of Biomedical Informatics, The Ohio State University Wexner Medical Center
- Cankun Wang
- Department of Biomedical Informatics, The Ohio State University Wexner Medical Center
- Anjun Ma
- Department of Biomedical Informatics, The Ohio State University Wexner Medical Center
- Qi Guo
- Department of Biomedical Informatics, The Ohio State University Wexner Medical Center
- Yi Li
- F.M. Kirby Neurobiology Center, Boston Children’s Hospital, Department of Neurology, Harvard Medical School
- Nicole Pukos
- Department of Neuroscience, The Ohio State University Wexner Medical Center
- Warren A. Campbell
- Department of Neuroscience, The Ohio State University Wexner Medical Center
- Kristina G. Witcher
- Department of Neuroscience, The Ohio State University Wexner Medical Center
- Zhen Guan
- Department of Neuroscience, The Ohio State University Wexner Medical Center
- Kristina A. Kigerl
- Department of Neuroscience, The Ohio State University Wexner Medical Center
- Jodie C. E. Hall
- Department of Neuroscience, The Ohio State University Wexner Medical Center
- Jonathan P. Godbout
- Department of Neuroscience, The Ohio State University Wexner Medical Center
- Andy J. Fischer
- Department of Neuroscience, The Ohio State University Wexner Medical Center
- Dana M. McTigue
- Department of Neuroscience, The Ohio State University Wexner Medical Center
- Zhigang He
- F.M. Kirby Neurobiology Center, Boston Children’s Hospital, Department of Neurology, Harvard Medical School
- Qin Ma
- Department of Biomedical Informatics, The Ohio State University Wexner Medical Center
- Phillip G. Popovich
- Department of Neuroscience, The Ohio State University Wexner Medical Center
- DOI
- https://doi.org/10.1038/s41467-022-31797-0
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 20
Abstract
Here the authors show, using microglia-specific depletion techniques and single cell transcriptomics, that optimal repair after murine spinal cord injury (SCI) requires microglia.
