Autophagy regulates Notch degradation and modulates stem cell development and neurogenesis

Xiaoting Wu; Angeleen Fleming; Thomas Ricketts; Mariana Pavel; Herbert Virgin; Fiona M. Menzies; David C. Rubinsztein

doi:10.1038/ncomms10533

Nature Communications (Feb 2016)

Autophagy regulates Notch degradation and modulates stem cell development and neurogenesis

Xiaoting Wu,
Angeleen Fleming,
Thomas Ricketts,
Mariana Pavel,
Herbert Virgin,
Fiona M. Menzies,
David C. Rubinsztein

Affiliations

Xiaoting Wu: Department of Medical Genetics, Cambridge Institute for Medical Research (CIMR), University of Cambridge
Angeleen Fleming: Department of Medical Genetics, Cambridge Institute for Medical Research (CIMR), University of Cambridge
Thomas Ricketts: Department of Medical Genetics, Cambridge Institute for Medical Research (CIMR), University of Cambridge
Mariana Pavel: Department of Medical Genetics, Cambridge Institute for Medical Research (CIMR), University of Cambridge
Herbert Virgin: Department of Pathology and Immunology, Washington University School of Medicine
Fiona M. Menzies: Department of Medical Genetics, Cambridge Institute for Medical Research (CIMR), University of Cambridge
David C. Rubinsztein: Department of Medical Genetics, Cambridge Institute for Medical Research (CIMR), University of Cambridge

DOI: https://doi.org/10.1038/ncomms10533
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 17

Abstract

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The molecular mechanisms behind how autophagy may impact on developmental pathways and cell fate decisions are unclear. Here Wu et al.identify Notch receptors being taken up into ATG16L1-positive autophagosomes and, using a mouse mutant model, show that changes in autophagy can impact on stem cell fate.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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