Genetic and Epigenetic Sexual Dimorphism of Brain Cells during Aging

Olesya Shirokova; Olga Zaborskaya; Pavel Pchelin; Elizaveta Kozliaeva; Vladimir Pershin; Irina Mukhina

doi:10.3390/brainsci13020195

Brain Sciences (Jan 2023)

Genetic and Epigenetic Sexual Dimorphism of Brain Cells during Aging

Olesya Shirokova,
Olga Zaborskaya,
Pavel Pchelin,
Elizaveta Kozliaeva,
Vladimir Pershin,
Irina Mukhina

Affiliations

Olesya Shirokova: Institute of Fundamental Medicine, Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Square, Nizhny Novgorod 603950, Russia
Olga Zaborskaya: Institute of Fundamental Medicine, Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Square, Nizhny Novgorod 603950, Russia
Pavel Pchelin: Institute of Fundamental Medicine, Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Square, Nizhny Novgorod 603950, Russia
Elizaveta Kozliaeva: Institute of Fundamental Medicine, Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Square, Nizhny Novgorod 603950, Russia
Vladimir Pershin: Institute of Fundamental Medicine, Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Square, Nizhny Novgorod 603950, Russia
Irina Mukhina: Institute of Fundamental Medicine, Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Square, Nizhny Novgorod 603950, Russia

DOI: https://doi.org/10.3390/brainsci13020195
Journal volume & issue: Vol. 13, no. 2
p. 195

Abstract

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In recent years, much of the attention paid to theoretical and applied biomedicine, as well as neurobiology, has been drawn to various aspects of sexual dimorphism due to the differences that male and female brain cells demonstrate during aging: (a) a dimorphic pattern of response to therapy for neurodegenerative disorders, (b) different age of onset and different degrees of the prevalence of such disorders, and (c) differences in their symptomatic manifestations in men and women. The purpose of this review is to outline the genetic and epigenetic differences in brain cells during aging in males and females. As a result, we hereby show that the presence of brain aging patterns in males and females is due to a complex of factors associated with the effects of sex chromosomes, which subsequently entails a change in signal cascades in somatic cells.

Published in Brain Sciences

ISSN: 2076-3425 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.mdpi.com/journal/brainsci/

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