Nature Communications (Jun 2022)
Adipocyte HIF2α functions as a thermostat via PKA Cα regulation in beige adipocytes
- Ji Seul Han,
- Yong Geun Jeon,
- Minsik Oh,
- Gung Lee,
- Hahn Nahmgoong,
- Sang Mun Han,
- Jeehye Choi,
- Ye Young Kim,
- Kyung Cheul Shin,
- Jiwon Kim,
- Kyuri Jo,
- Sung Sik Choe,
- Eun Jung Park,
- Sun Kim,
- Jae Bum Kim
Affiliations
- Ji Seul Han
- Center for Adipocyte Structure and Function, Institute of Molecular Biology and Genetics, School of Biological Sciences, Seoul National University
- Yong Geun Jeon
- Center for Adipocyte Structure and Function, Institute of Molecular Biology and Genetics, School of Biological Sciences, Seoul National University
- Minsik Oh
- School of Software Convergence, Myongji University
- Gung Lee
- Center for Adipocyte Structure and Function, Institute of Molecular Biology and Genetics, School of Biological Sciences, Seoul National University
- Hahn Nahmgoong
- Center for Adipocyte Structure and Function, Institute of Molecular Biology and Genetics, School of Biological Sciences, Seoul National University
- Sang Mun Han
- Center for Adipocyte Structure and Function, Institute of Molecular Biology and Genetics, School of Biological Sciences, Seoul National University
- Jeehye Choi
- Center for Adipocyte Structure and Function, Institute of Molecular Biology and Genetics, School of Biological Sciences, Seoul National University
- Ye Young Kim
- Center for Adipocyte Structure and Function, Institute of Molecular Biology and Genetics, School of Biological Sciences, Seoul National University
- Kyung Cheul Shin
- Center for Adipocyte Structure and Function, Institute of Molecular Biology and Genetics, School of Biological Sciences, Seoul National University
- Jiwon Kim
- Center for Adipocyte Structure and Function, Institute of Molecular Biology and Genetics, School of Biological Sciences, Seoul National University
- Kyuri Jo
- Department of Computer Engineering, Chungbuk National University
- Sung Sik Choe
- Center for Adipocyte Structure and Function, Institute of Molecular Biology and Genetics, School of Biological Sciences, Seoul National University
- Eun Jung Park
- Cancer Immunology Branch, Department of System Cancer Science, National Cancer Center
- Sun Kim
- Department of Computer Science and Engineering, Seoul National University
- Jae Bum Kim
- Center for Adipocyte Structure and Function, Institute of Molecular Biology and Genetics, School of Biological Sciences, Seoul National University
- DOI
- https://doi.org/10.1038/s41467-022-30925-0
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
Thermogenic adipocytes maintain body temperature in response to cold, but how this is tuned during cold and re-warming is unclear. Here, the authors show HIF2α inhibits beige adipocyte retention, regulating PKA catalysis to control dynamic adipocyte remodelling.
