Nature Communications (Jan 2023)
The classical pathway triggers pathogenic complement activation in membranous nephropathy
- Larissa Seifert,
- Gunther Zahner,
- Catherine Meyer-Schwesinger,
- Naemi Hickstein,
- Silke Dehde,
- Sonia Wulf,
- Sarah M. S. Köllner,
- Renke Lucas,
- Dominik Kylies,
- Sarah Froembling,
- Stephanie Zielinski,
- Oliver Kretz,
- Anna Borodovsky,
- Sergey Biniaminov,
- Yanyan Wang,
- Hong Cheng,
- Friedrich Koch-Nolte,
- Peter F. Zipfel,
- Helmut Hopfer,
- Victor G. Puelles,
- Ulf Panzer,
- Tobias B. Huber,
- Thorsten Wiech,
- Nicola M. Tomas
Affiliations
- Larissa Seifert
- III. Department of Medicine, University Medical Center Hamburg-Eppendorf
- Gunther Zahner
- III. Department of Medicine, University Medical Center Hamburg-Eppendorf
- Catherine Meyer-Schwesinger
- Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf
- Naemi Hickstein
- III. Department of Medicine, University Medical Center Hamburg-Eppendorf
- Silke Dehde
- III. Department of Medicine, University Medical Center Hamburg-Eppendorf
- Sonia Wulf
- Institute of Pathology, Nephropathology Section, University Medical Center Hamburg-Eppendorf
- Sarah M. S. Köllner
- III. Department of Medicine, University Medical Center Hamburg-Eppendorf
- Renke Lucas
- III. Department of Medicine, University Medical Center Hamburg-Eppendorf
- Dominik Kylies
- III. Department of Medicine, University Medical Center Hamburg-Eppendorf
- Sarah Froembling
- Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf
- Stephanie Zielinski
- Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf
- Oliver Kretz
- III. Department of Medicine, University Medical Center Hamburg-Eppendorf
- Anna Borodovsky
- Alnylam Pharmaceuticals
- Sergey Biniaminov
- HS Analysis GmbH
- Yanyan Wang
- Division of Nephrology, Beijing Anzhen Hospital, Capital Medical University
- Hong Cheng
- Division of Nephrology, Beijing Anzhen Hospital, Capital Medical University
- Friedrich Koch-Nolte
- Institute of Immunology, University Medical Center Hamburg-Eppendorf
- Peter F. Zipfel
- Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute
- Helmut Hopfer
- Department of Medical Genetics and Pathology, University Hospital Basel, University of Basel
- Victor G. Puelles
- III. Department of Medicine, University Medical Center Hamburg-Eppendorf
- Ulf Panzer
- III. Department of Medicine, University Medical Center Hamburg-Eppendorf
- Tobias B. Huber
- III. Department of Medicine, University Medical Center Hamburg-Eppendorf
- Thorsten Wiech
- Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf
- Nicola M. Tomas
- III. Department of Medicine, University Medical Center Hamburg-Eppendorf
- DOI
- https://doi.org/10.1038/s41467-023-36068-0
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 18
Abstract
It is generally thought that complement activation in human membranous nephropathy (MN) occurs predominantly via the lectin or alternative pathway. Here, the authors show that the classical pathway is the dominant form of complement activation in MN and a pathogenic driver of the disease.
