International Journal of Infectious Diseases (Feb 2019)

Molecular diagnosis of toxoplasmosis at the onset of symptomatic primary infection: A straightforward alternative to serological examinations

  • Maude F. Lévêque,
  • Delphine Chiffré,
  • Chloé Galtier,
  • Sahar Albaba,
  • Christophe Ravel,
  • Laurence Lachaud,
  • Anaïs Iemmi,
  • Pierre Flori,
  • Yvon Sterkers

Journal volume & issue
Vol. 79
pp. 131 – 133

Abstract

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Myopericarditis is a rare but well-documented clinical presentation of primary Toxoplasma gondii infection in immunocompetent patients. Here, early detection of Toxoplasma DNA in the peripheral blood by PCR allowed the diagnosis of acute toxoplasmosis while serological tests were negative. Additional serological evaluations 2 weeks later confirmed the diagnosis and showed that cardiac manifestations occurred before seroconversion. This highlights the importance of a second serological control in the case of a suspected active infection. Overall, we show here that PCR testing for Toxoplasma is a sensitive and straightforward alternative to serological examinations. Keywords: Acute toxoplasmosis, Myopericarditis, Immunocompetent, Toxoplasma gondii, PCR, Second serological control, Molecular diagnosis