Synbiotic Effects of <i>Saccharomyces</i><i>cerevisiae</i>, Mannan Oligosaccharides, and β-Glucan on Innate Immunity, Antioxidant Status, and Disease Resistance of Nile Tilapia, <i>Oreochromis niloticus</i>
Gamal El-Nobi,
Mohammed Hassanin,
Alshimaa A. Khalil,
Alaa Y. Mohammed,
Shimaa A. Amer,
Metwally M. Montaser,
Mohamed E. El-sharnouby
Affiliations
Gamal El-Nobi
Department of fish diseases and management, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44511, Egypt
Mohammed Hassanin
Department of fish diseases and management, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44511, Egypt
Alshimaa A. Khalil
Department of fish diseases and management, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44511, Egypt
Alaa Y. Mohammed
Department of fish diseases and management, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44511, Egypt
Shimaa A. Amer
Department of Nutrition and Clinical Nutrition, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44511, Egypt
Metwally M. Montaser
Science and Technology Department, Ranyah University College, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia
Mohamed E. El-sharnouby
Department of Biotechnology, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia
Synbiotic (SYN) additives were assessed as an antibiotic alternative on the effects on the nonspecific immune response and disease resistance of O. niloticus to P. aeruginosa. Healthy fish (n = 120, average initial weight 18 ± 2 g) were allotted randomly into four experimental groups (3 replicates for each); 1) a control group with no additives (CON), 2) basal diet complemented with 0.1 g kg–1 diets of norfloxacin, NFLX, 3) basal diet fortified with 1 mL kg–1 diet of SYN, and 4) basal diet complemented with a mixture of NFLX and SYN, which was carried out for eight weeks. Results showed a significant increase (p O. niloticus following the P. aeruginosa challenge was decreased in the SYN group compared to other groups. The results emphasize that synbiotic could be used as a norfloxacin alternative to enhance the related immunological parameters, including antioxidant activity and disease resistance against P. aeruginosa infection of O. niloticus.
