Electrocardiographic ventricular arrhythmia parameters during diagnosis and after the treatment of acromegaly: A case-control study
Zeynep Zehra Tekin,
Hilal Erken Pamukcu,
Serdar Kayihan,
Bekir Ucan,
Hayri Bostan,
Umran Gul,
Hakan Duger,
Sema Hepsen,
Erman Cakal,
Seyit Ibrahim Akdag,
Muhammed Kizilgul
Affiliations
Zeynep Zehra Tekin
Etlik City Hospital, Department of Internal Medicine, Varlık Mahallesi, Halil Sezai Erkut Caddesi Yenimahalle, Ankara, Turkey; Sanliurfa Training and Research Hospital, Depeartment of Internal Medicine, Varlık Mahallesi, Halil Sezai Erkut Caddesi Yenimahalle, Turkey; Corresponding author. Sanliurfa Training and Research Hospital, Yenice Mah., Yenice Yolu No:1, 63250 Eyyübiye, Sanliurfa, Turkey.
Hilal Erken Pamukcu
Etlik City Hospital, Department of Cardiology, Varlık Mahallesi, Halil Sezai Erkut Caddesi Yenimahalle, Ankara, Turkey
Serdar Kayihan
Etlik City Hospital, Department of Endocrinology and Metabolism, Varlık Mahallesi, Halil Sezai Erkut Caddesi Yenimahalle, Ankara, Turkey
Bekir Ucan
Etlik City Hospital, Department of Endocrinology and Metabolism, Varlık Mahallesi, Halil Sezai Erkut Caddesi Yenimahalle, Ankara, Turkey
Hayri Bostan
Etlik City Hospital, Department of Endocrinology and Metabolism, Varlık Mahallesi, Halil Sezai Erkut Caddesi Yenimahalle, Ankara, Turkey
Umran Gul
Etlik City Hospital, Department of Endocrinology and Metabolism, Varlık Mahallesi, Halil Sezai Erkut Caddesi Yenimahalle, Ankara, Turkey
Hakan Duger
Etlik City Hospital, Department of Endocrinology and Metabolism, Varlık Mahallesi, Halil Sezai Erkut Caddesi Yenimahalle, Ankara, Turkey
Sema Hepsen
Etlik City Hospital, Department of Endocrinology and Metabolism, Varlık Mahallesi, Halil Sezai Erkut Caddesi Yenimahalle, Ankara, Turkey
Erman Cakal
Etlik City Hospital, Department of Endocrinology and Metabolism, Varlık Mahallesi, Halil Sezai Erkut Caddesi Yenimahalle, Ankara, Turkey
Seyit Ibrahim Akdag
Etlik City Hospital, Department of Internal Medicine, Varlık Mahallesi, Halil Sezai Erkut Caddesi Yenimahalle, Ankara, Turkey
Muhammed Kizilgul
Etlik City Hospital, Department of Endocrinology and Metabolism, Varlık Mahallesi, Halil Sezai Erkut Caddesi Yenimahalle, Ankara, Turkey
Background: The risk of death is increased in acromegaly patients compared to the general population, and cardiovascular system-related complications are among the risk factors decreasing life expectancy. The Tp-e interval, which is the distance between the point where the T-wave peaks and ends on electrocardiography (ECG), shows ventricular rapolarization and, together with the Tp-e/QT and Tp-e/QTc ratios, these are relatively new tools that predict ventricular arrhythmia. We aimed to evaluate the ECG of acromegaly patients at the time of diagnosis and compare the results with current ECG findings. Material and methods: The study included 103 acromegaly patients and 81 control subjects. Of the 103 patients, 41 patients had only baseline ECG, 23 patients had only current ECG and 39 patients had both baseline and current ECGs. Heart rate, QT interval and corrected QT (QTc) interval, Tp-e, Tp-e/QT, Tp-e/QTc values on the ECGs were measured by a cardiologist. Results: In the acromegaly patients with both baseline and current ECGs, heart rate, QRS duration, Tp-e, and Tp-e/QTc ratio were decreased. The decrease in these arrhythmia parameters was similar in active and remission patients. Compared to the control group, in acromegaly patients with only baseline ECG, heart rate, QTc interval, Tp-e, Tp-e/QT, and Tp-e/QTc were decreased. Conclusion: Ventricular arrhythmia parameters improve with treatment in patients with acromegaly. The decrease in ventricular arrhythmia parameters was similar in active and remission patients, which can be explained by the significant decrease in IGF-1 levels compared to the time of diagnosis, even in patients with active disease.
