Emerging lactic acid bacteria bacteriocins as anti-cancer and anti-tumor agents for human health
Alaa Kareem Niamah,
Shayma Thyab Gddoa Al-Sahlany,
Deepak Kumar Verma,
Rakesh Mohan Shukla,
Ami R. Patel,
Soubhagya Tripathy,
Smita Singh,
Deepika Baranwal,
Amit Kumar Singh,
Gemilang Lara Utama,
Mónica L. Chávez González,
Wissal Audah Hassan Alhilfi,
Prem Prakash Srivastav,
Cristobal Noe. Aguilar
Affiliations
Alaa Kareem Niamah
Department of Food Science, College of Agriculture, University of Basrah, Basra City, Iraq
Shayma Thyab Gddoa Al-Sahlany
Department of Food Science, College of Agriculture, University of Basrah, Basra City, Iraq
Deepak Kumar Verma
Agricultural and Food Engineering Department, Indian Institute of Technology Kharagpur, Kharagpur 721302, West Bengal, India; Corresponding author.
Rakesh Mohan Shukla
Processing and Food Engineering Division, College of Agricultural Engineering and Technology (CoAE&T), Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir, Srinagar, 190 025, Jammu and Kashmir, India
Ami R. Patel
Division of Dairy Microbiology, Mansinhbhai Institute of Dairy and Food Technology-MIDFT, Dudhsagar Dairy Campus, Mehsana-384 002, Gujarat, India
Soubhagya Tripathy
Agricultural and Food Engineering Department, Indian Institute of Technology Kharagpur, Kharagpur 721302, West Bengal, India
Smita Singh
Department of Allied Health Sciences, Chitkara School of Health Sciences, Chitkara University, Punjab 140401, India
Deepika Baranwal
Department of Home Science, Arya Mahila PG College, Banaras Hindu University, Varanasi, Uttar Pradesh, 221005, India
Amit Kumar Singh
Department of Post Harvest Technology, College of Horticulture, Banda University of Agriculture and Technology, Banda 210 001, Uttar Pradesh, India
Gemilang Lara Utama
Faculty of Agro-Industrial Technology, Universitas Padjadjaran, Sumedang 45363, Indonesia; Center for Environment and Sustainability Science, Universitas Padjadjaran, Bandung 40132, Indonesia
Mónica L. Chávez González
Bioprocesses and Bioproducts Group, Food Research Department, School of Chemistry, Universidad Autónoma de Coahuila, Saltillo Campus., 25280, Coahuila, Mexico
Wissal Audah Hassan Alhilfi
Marine Science Center, University of Basrah, Basra City, Iraq
Prem Prakash Srivastav
Agricultural and Food Engineering Department, Indian Institute of Technology Kharagpur, Kharagpur 721302, West Bengal, India
Cristobal Noe. Aguilar
Bioprocesses and Bioproducts Group, Food Research Department, School of Chemistry, Universidad Autónoma de Coahuila, Saltillo Campus., 25280, Coahuila, Mexico; Corresponding author. Bioprocesses and Bioproducts Group, Food Research Department, School of Chemistry. Autonomous University of Coahuila, Saltillo Campus. 25280. Coahuila, Mexico.
Modern cancer diagnostics and treatment options have greatly improved survival rates; the illness remains a major cause of mortality worldwide. Current treatments for cancer, such as chemotherapy, are not cancer-specific and may cause harm to healthy cells; therefore, it is imperative that new drugs for cancer be developed that are both safe and effective. It has been found that lactic acid bacteria (LAB) have the potential to produce bacteriocins, which could potentially offer a promising alternative for cancer treatment. They have been shown in several studies to be effective against cancer cells while having no effect on healthy cells. More research is needed to fully understand the potential of LAB bacteriocins as anti-cancer medicines, to find the appropriate dose and delivery route, and to conduct clinical trials to evaluate the effectiveness and safety of the products in human patients, as is suggested by this work. Furthermore, LAB bacteriocins may evolve into a significant new class of anti-cancer drugs and food products. Patients with cancer may have a safe and effective alternative treatment option in the form of anti-cancer foods and drugs. Therefore, the aim of this study is to provide an in-depth analysis of the recent breakthroughs and potential future technical advancements of significant bacteriocins that are produced by LAB, how these bacteriocins function, and how these bacteriocins may be utilized as an anti-cancer agent. In addition, the current analysis emphasizes the significant constraints and boundaries that bacteriocins face when they are used as an anti-cancer factor.
