Molecules (Jan 2020)

Oxidative Dearomative Cross-Dehydrogenative Coupling of Indoles with Diverse C-H Nucleophiles: Efficient Approach to 2,2-Disubstituted Indolin-3-ones

  • Xue Yan,
  • Ying-De Tang,
  • Cheng-Shi Jiang,
  • Xigong Liu,
  • Hua Zhang

DOI
https://doi.org/10.3390/molecules25020419
Journal volume & issue
Vol. 25, no. 2
p. 419

Abstract

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The oxidative, dearomative cross-dehydrogenative coupling of indoles with various C-H nucleophiles is developed. This process features a broad substrate scope with respect to both indoles and nucleophiles, affording structurally diverse 2,2-disubstituted indolin-3-ones in high yields (up to 99%). The oxidative dimerization and trimerization of indoles has also been demonstrated under the same conditions.

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