African Journal of Urology (Dec 2020)

Overactive bladder symptoms recurrence after sudden versus gradual weaning of Solifenacin

  • Ahmed Abdelbary,
  • Ahmad Aref Al-Dessoukey,
  • Ayman Salah Moussa,
  • Mohamed Saif El-nasr,
  • Akrm Ahmed Elmarakbi,
  • Ahmed Medhat Ragheb,
  • Ahmed Mohamed Elbatanouny,
  • Ahmed Abdellateef,
  • Osama Sayed,
  • Amr Lotfy,
  • Khaled Mohyelden,
  • Amr Mohamad Abdelhamid,
  • Ehab Mohamad Galal,
  • Amr Massoud,
  • Rabie M. Ibrahim

DOI
https://doi.org/10.1186/s12301-020-00100-2
Journal volume & issue
Vol. 26, no. 1
pp. 1 – 6

Abstract

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Abstract Background To evaluate and compare the recurrence rate of overactive bladder (OAB) symptoms after solifenacin treatment in patients who stop the drug suddenly versus those who gradually wean the drug after improvement of their condition. Methods Our study included 60 patients with idiopathic OAB and treated with solifenacin 5 mg twice daily for one month. After improvement of their condition, we divided the responders into two groups, group I stopped the drug suddenly, while group II underwent gradual weaning of the drug. Results The recurrence rate of symptoms of OAB was 33.3% and 60% after 1 and 3 months in patients who stopped the solifenacin suddenly after improvement of their symptoms, while it was 6.7% and 23.3% after 1 and 3 months in patients who gradually weaned solifenacin. Conclusion After the improvement of OAB symptoms, gradual weaning of solifenacin can help in decreasing the recurrence rate of symptoms.

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