New Derivatives of 3,4-Dihydroisoquinoline-3-carboxylic Acid with Free-Radical Scavenging, D-Amino Acid Oxidase, Acetylcholinesterase and Butyrylcholinesterase Inhibitory Activity
Jolanta Solecka,
Adam Guśpiel,
Magdalena Postek,
Joanna Ziemska,
Robert Kawęcki,
Katarzyna Łęczycka,
Agnieszka Osior,
Bartłomiej Pietrzak,
Krzysztof Pypowski,
Agata Wyrzykowska
Affiliations
Jolanta Solecka
National Institute of Public Health—National Institute of Hygiene, Chocimska 24, Warsaw 00-791, Poland
Adam Guśpiel
National Institute of Public Health—National Institute of Hygiene, Chocimska 24, Warsaw 00-791, Poland
Magdalena Postek
National Institute of Public Health—National Institute of Hygiene, Chocimska 24, Warsaw 00-791, Poland
Joanna Ziemska
National Institute of Public Health—National Institute of Hygiene, Chocimska 24, Warsaw 00-791, Poland
Robert Kawęcki
Institute of Chemistry, Siedlce University, 3.Maja 54, Siedlce 80-110, Poland
Katarzyna Łęczycka
Institute of Chemistry, Siedlce University, 3.Maja 54, Siedlce 80-110, Poland
Agnieszka Osior
Institute of Chemistry, Siedlce University, 3.Maja 54, Siedlce 80-110, Poland
Bartłomiej Pietrzak
Institute of Chemistry, Siedlce University, 3.Maja 54, Siedlce 80-110, Poland
Krzysztof Pypowski
Institute of Chemistry, Siedlce University, 3.Maja 54, Siedlce 80-110, Poland
Agata Wyrzykowska
Institute of Chemistry, Siedlce University, 3.Maja 54, Siedlce 80-110, Poland
A series of 3,4-dihydroisoquinoline-3-carboxylic acid derivatives were synthesised and tested for their free-radical scavenging activity using 2,2-diphenyl-1-picrylhydrazyl radical (DPPH·), 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) radical (ABTS·+), superoxide anion radical (O2·−) and nitric oxide radical (·NO) assays. We also studied D-amino acid oxidase (DAAO), acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitory activity. Almost each of newly synthesised compounds exhibited radical scavenging capabilities. Moreover, several compounds showed moderate inhibitory activities against DAAO, AChE and BuChE. Compounds with significant free-radical scavenging activity may be potential candidates for therapeutics used in oxidative-stress-related diseases.
