Clinical factors associated with smoking cessation among smokers with Chronic Obstructive Pulmonary Disease by sex: Longitudinal analyses from French smoking cessation services
Ingrid Allagbé,
Roche Nicolas,
Guillaume Airagnes,
Limosin Frédéric,
Abdel-Ali Boussadi,
Anne-Laurence Le Faou
Affiliations
Ingrid Allagbé
Centre Ambulatoire d'Addictologie, Hôpital Européen Georges Pompidou, Département Médico-Universitaire de Psychiatrie et Addictologie, AP-HP. Centre - Université Paris Cité, Paris, France; Groupement d’Intérêt Scientifique du Réseau Français d’Excellence de Recherche sur le tabac, la nicotine et les produits connexes (REFERtab), Paris, France; Corresponding author. Centre Ambulatoire d'Addictologie, Hôpital Européen Georges Pompidou, Département Médico-Universitaire de Psychiatrie et Addictologie, AP-HP.Centre - Université Paris Cité, Paris, France.
Roche Nicolas
Respiratory and Intensive Care Medicine, Hôpital Cochin, AP-HP. Centre - Université Paris Cité (EA2511), Paris, France
Guillaume Airagnes
Centre Ambulatoire d'Addictologie, Hôpital Européen Georges Pompidou, Département Médico-Universitaire de Psychiatrie et Addictologie, AP-HP. Centre - Université Paris Cité, Paris, France; UMS 011, Population-based Epidemiological Cohorts, Inserm, Villejuif, France
Limosin Frédéric
Département de Psychiatrie, Hôpital Corentin-Celton, Centre Université Paris Cité, AP-HP, Issy-les-Moulineaux, France; INSERM, Institut de Psychiatrie et Neurosciences de Paris, Paris, France; Faculté de Santé, UFR de Médecine, Université Paris Cité, Paris, France
Abdel-Ali Boussadi
Département de Santé Publique et Informatique Médicale, Hôpital Européen Georges Pompidou, AP-HP. Centre - Université Paris Cité, Paris, France; INSERM UMR 1138, Equipe 22, Centre de Recherche des Cordeliers, Paris, France
Anne-Laurence Le Faou
Centre Ambulatoire d'Addictologie, Hôpital Européen Georges Pompidou, Département Médico-Universitaire de Psychiatrie et Addictologie, AP-HP. Centre - Université Paris Cité, Paris, France; Respiratory and Intensive Care Medicine, Hôpital Cochin, AP-HP. Centre - Université Paris Cité (EA2511), Paris, France; Groupement d’Intérêt Scientifique du Réseau Français d’Excellence de Recherche sur le tabac, la nicotine et les produits connexes (REFERtab), Paris, France
Background: Smoking is responsible for 80 % of cases of Chronic Obstructive Pulmonary Disease (COPD), while the prognosis is improved by smoking cessation (SC). We examined clinical factors associated with SC among smokers with COPD comparing women and men. Methods: The study comprised a cohort of 1470 smokers who visited a SC service and completed at least 28-day of follow-up visits. The outcome was smoking status at follow-up (abstinence, reduction, no change). Abstinence was defined as continuous abstinence for at least 28 days, validated by the measurement of expired Carbon Monoxide. Reduction was defined as a halving of the baseline tobacco consumption. Results: The average age of the population was 53 (±11) years and 58.2 % were women. Men were 2 years younger than women and consulted more likely after a hospital contact, whereas women consulted on their own initiative. Women more often had a depression history, whereas men had medical comorbidities and co-addictions. There was no significant difference by sex regarding the abstinence rate (41.0 % in women vs 40.7 in men, p > 0.9). The factors significantly associated with higher abstinence rates in both sexes were: at least one previous quit attempt and number of follow-up visits ≥4. The factors negatively associated with quitting in women were diabetes, intake of mood stabilizers and consuming more than 10 cigarettes per day while having a chronic bronchitis, taking antidepressants and having consumed cannabis in the last 30 days hampered SC in men. Conclusions: Concerning factors associated with SC, few differences were found between female and male smokers suffering from COPD. However, due to the different medical and smoking behavior characteristics according to sex, it might be important to take these differences into account in order to provide tailored SC management.
