(7R,8S,9S,12S)-1-(4-Chlorobenzyloxy)-13,14-didehydro-12-hydroxy-2,13-dimethoxy-N-methylmorphinane

Abstract

The title compound, C26H30ClNO4, a sinomenine derivative, has five six-membered rings, two of which are aromatic, with a dihedral angle of 34.13 (20)° between these. The N-containing ring and the fourth ring exhibit chair conformations, while the fifth ring approximates an envelope conformation. A single intermolecular O—H...N hydrogen-bonding interaction gives a one-dimensional chain structure which extends along the a axis. The absolute configuration for the molecule has been determined.