Molecules (Aug 2011)

Azaphenanthrene Alkaloids with Antitumoral Activity from Anaxagorea dolichocarpa Sprague & Sandwith (Annonaceae)

  • Josean Fechine Tavares,
  • Emidio V.L. Da-Cunha,
  • Marcelo Sobral Da Silva,
  • Maria De Fátima Agra,
  • Margareth De Fátima Formiga Melo Diniz,
  • Marianna Vieira Sobral Castello Branco,
  • Ana Silvia Suassuna Carneiro Lúcio,
  • João Carlos Lima Rodrigues Pita,
  • José Maria Barbosa-Filho,
  • Jackson Roberto Guedes Da Silva Almeida

DOI
https://doi.org/10.3390/molecules16087125
Journal volume & issue
Vol. 16, no. 8
pp. 7125 – 7131

Abstract

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Phytochemical investigation of Anaxagorea dolichocarpa Sprague & Sandwith led to isolation of three azaphenanthrene alkaloids: eupolauramine, sampangine and imbiline 1. Their chemical structures were established on the basis of spectroscopic data from IR, HR-ESI-MS, NMR (including 2D experiments) and comparison with the literature. Sampangine and imbiline 1 are being described in the Anaxagorea genus for the first time. Eupolauramine and sampangine show concentration-dependent antitumoral activity in leukemic cells K562 with IC50 of 18.97 and 10.95 µg/mL, respectively.

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