Nature Communications (May 2021)
Symmetry breaking of tissue mechanics in wound induced hair follicle regeneration of laboratory and spiny mice
- Hans I-Chen Harn,
- Sheng-Pei Wang,
- Yung-Chih Lai,
- Ben Van Handel,
- Ya-Chen Liang,
- Stephanie Tsai,
- Ina Maria Schiessl,
- Arijita Sarkar,
- Haibin Xi,
- Michael Hughes,
- Stefan Kaemmer,
- Ming-Jer Tang,
- Janos Peti-Peterdi,
- April D. Pyle,
- Thomas E. Woolley,
- Denis Evseenko,
- Ting-Xin Jiang,
- Cheng-Ming Chuong
Affiliations
- Hans I-Chen Harn
- Department of Pathology, Keck School of Medicine, University of Southern California
- Sheng-Pei Wang
- Department of Pathology, Keck School of Medicine, University of Southern California
- Yung-Chih Lai
- Integrative Stem Cell Center, China Medical University Hospital, China Medical University
- Ben Van Handel
- Department of Orthopaedic Surgery, Keck School of Medicine, University of Southern California
- Ya-Chen Liang
- Department of Pathology, Keck School of Medicine, University of Southern California
- Stephanie Tsai
- Department of Pathology, Keck School of Medicine, University of Southern California
- Ina Maria Schiessl
- Department of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California
- Arijita Sarkar
- Department of Orthopaedic Surgery, Keck School of Medicine, University of Southern California
- Haibin Xi
- Department of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles
- Michael Hughes
- International Research Center of Wound Repair and Regeneration (iWRR), National Cheng Kung University
- Stefan Kaemmer
- Park Systems Inc.
- Ming-Jer Tang
- International Research Center of Wound Repair and Regeneration (iWRR), National Cheng Kung University
- Janos Peti-Peterdi
- Department of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California
- April D. Pyle
- Department of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles
- Thomas E. Woolley
- Cardiff School of Mathematics, Cardiff University
- Denis Evseenko
- Department of Orthopaedic Surgery, Keck School of Medicine, University of Southern California
- Ting-Xin Jiang
- Department of Pathology, Keck School of Medicine, University of Southern California
- Cheng-Ming Chuong
- Department of Pathology, Keck School of Medicine, University of Southern California
- DOI
- https://doi.org/10.1038/s41467-021-22822-9
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 16
Abstract
How hair follicle regeneration arises readily in some species ie. spiny rather than laboratory mice, is unclear. Here, authors compare them, showing an optimal stiffness is needed for placode formation and the difference in hair follicle regenerative behaviour after wounding is linked to Twist1.
